Heritable Skeletal Disorders Arising from Defects in Processing and Transport of Type I Procollagen from the ER: Perspectives on Possible Therapeutic Approaches.
Sign Up to like & getrecommendations! Published in 2018 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2017_67
Abstract: Rare bone disorders are a heterogeneous group of diseases, initially associated with mutations in type I procollagen (PC) genes. Recent developments from dissection at the molecular and cellular level have expanded the list of disease-causing… read more here.
Keywords: transport; possible therapeutic; type procollagen; skeletal disorders ... See more keywords
The multifaced role of HtrA1 in the development of joint and skeletal disorders.
Sign Up to like & getrecommendations! Published in 2022 at "Bone"
DOI: 10.1016/j.bone.2022.116350
Abstract: HtrA1 (High temperature requirement A1) family proteins include four members, widely conserved from prokaryotes to eukaryotes, named HtrA1, HtrA2, HtrA3 and HtrA4. HtrA1 is a serine protease involved in a variety of biological functions regulating… read more here.
Keywords: htra1; skeletal disorders; role htra1; role ... See more keywords
Non-infectious skeletal disorders in broilers
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DOI: 10.1080/00439339.2020.1759388
Abstract: SUMMARY The incidence of non-infectious skeletal disorders has been reported to increase over the past decade. Both genetic selection and rearing conditions cause skeletal disorders in the broilers. The rapid increase in broiler body weight,… read more here.
Keywords: infectious skeletal; disorders broilers; non infectious; skeletal disorders ... See more keywords
The evolving therapeutic landscape of genetic skeletal disorders
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DOI: 10.1186/s13023-019-1222-2
Abstract: BackgroundRare bone diseases account for 5% of all birth defects yet very few have personalised treatments. Developments in genetic diagnosis, molecular techniques and treatment technologies however, are leading to unparalleled therapeutic advance. This review explores… read more here.
Keywords: therapeutic landscape; genetic skeletal; skeletal disorders; landscape genetic ... See more keywords
Safety Evaluation of Natural Drugs in Chronic Skeletal Disorders: A Literature Review of Clinical Trials in the Past 20 years
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DOI: 10.3389/fphar.2021.801287
Abstract: Chronic skeletal disorders (CSDs), including degenerative diseases such as osteoporosis (OP) and autoimmune disorders, have become a leading cause of disability in an ageing society, with natural drugs being indispensable therapeutic options. The clinical safety… read more here.
Keywords: safety; safety evaluation; chronic skeletal; skeletal disorders ... See more keywords