Skeletal Editing Approach to Bridge-Functionalized Bicyclo[1.1.1]pentanes from Azabicyclo[2.1.1]hexanes.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.3c02616
Abstract: Azabicyclo[2.1.1]hexanes (aza-BCHs) and bicyclo[1.1.1]pentanes (BCPs) have emerged as attractive classes of sp3-rich cores for replacing flat, aromatic groups with metabolically resistant, three-dimensional frameworks in drug scaffolds. Strategies to directly convert, or "scaffold hop", between these… read more here.
Keywords: bicyclo pentanes; skeletal editing; approach bridge; azabicyclo hexanes ... See more keywords
Recent Advances in the Dearomative Skeletal Editing of Mono-azaarenes
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DOI: 10.1055/a-2013-9885
Abstract: Despite challenging, skeletal editing of mono-azaarens (pyridines, quinolines and isoquinolines) has shown peerless synthetic charm in the construction of complex molecules that are difficult to access by conventional methods. In this short review, we summarize… read more here.
Keywords: skeletal editing; mono azaarenes; editing mono; recent advances ... See more keywords