Skeletal Muscle Mitochondrial Respiration and Exercise Intolerance in Patients With Heart Failure With Preserved Ejection Fraction.
Sign Up to like & getrecommendations! Published in 2023 at "JAMA cardiology"
DOI: 10.1001/jamacardio.2023.0957
Abstract: Importance The pathophysiology of exercise intolerance in patients with heart failure with preserved ejection fraction (HFpEF) remains incompletely understood. Multiple lines of evidence suggest that abnormal skeletal muscle metabolism is a key contributor, but the… read more here.
Keywords: exercise; muscle; exercise intolerance; muscle mitochondrial ... See more keywords
Overexpression of UCP3 decreases mitochondrial efficiency in mouse skeletal muscle in vivo
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14494
Abstract: Uncoupling protein‐3 (UCP3) is a mitochondrial transmembrane protein highly expressed in the muscle that has been implicated in regulating the efficiency of mitochondrial oxidative phosphorylation. Increasing UCP3 expression in skeletal muscle enhances proton leak across… read more here.
Keywords: overexpression ucp3; vivo; muscle; efficiency ... See more keywords
T‐type calcium channel blockade induces apoptosis in C2C12 myotubes and skeletal muscle via endoplasmic reticulum stress activation
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12965
Abstract: Loss of T‐type calcium channel (TCC) function has been reported to result in decreased cell viability and impaired muscle regeneration, but the underlying mechanisms remain largely unknown. We previously found that expression of TCC is… read more here.
Keywords: skeletal muscle; endoplasmic reticulum; muscle; c2c12 myotubes ... See more keywords
Vascularized and Innervated Skeletal Muscle Tissue Engineering.
Sign Up to like & getrecommendations! Published in 2019 at "Advanced healthcare materials"
DOI: 10.1002/adhm.201900626
Abstract: Volumetric muscle loss (VML) is a devastating loss of muscle tissue that overwhelms the native regenerative properties of skeletal muscle and results in lifelong functional deficits. There are currently no treatments for VML that fully… read more here.
Keywords: skeletal muscle; muscle; tissue; muscle tissue ... See more keywords
Integration of Graphene Electrodes with 3D Skeletal Muscle Tissue Models.
Sign Up to like & getrecommendations! Published in 2020 at "Advanced healthcare materials"
DOI: 10.1002/adhm.201901137
Abstract: Integration of conductive electrodes with 3D tissue models can have great potential for applications in bioelectronics, drug screening, and implantable devices. As conventional electrodes cannot be easily integrated on 3D, polymeric, and biocompatible substrates, alternatives… read more here.
Keywords: skeletal muscle; integration; graphene; tissue models ... See more keywords
Nanomaterial Additives for Fabrication of Stimuli-Responsive Skeletal Muscle Tissue Engineering Constructs.
Sign Up to like & getrecommendations! Published in 2020 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202000730
Abstract: Volumetric muscle loss necessitates novel tissue engineering strategies for skeletal muscle repair, which have traditionally involved cells and extracellular matrix-mimicking scaffolds and have thus far been unable to successfully restore physiologically relevant function. However, the… read more here.
Keywords: skeletal muscle; muscle; nanomaterial additives; tissue engineering ... See more keywords
Functional Skeletal Muscle Regeneration Using Muscle Mimetic Tissue Fabricated by Microvalve‐Assisted Coaxial 3D Bioprinting
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202202664
Abstract: 3D‐printed artificial skeletal muscle, which mimics the structural and functional characteristics of native skeletal muscle, is a promising treatment method for muscle reconstruction. Although various fabrication techniques for skeletal muscle using 3D bio‐printers are studied,… read more here.
Keywords: microvalve assisted; assisted coaxial; muscle; skeletal muscle ... See more keywords
Neutrophils Enable Local and Non-Invasive Liposome Delivery to Inflamed Skeletal Muscle and Ischemic Heart.
Sign Up to like & getrecommendations! Published in 2020 at "Advanced materials"
DOI: 10.1002/adma.202003598
Abstract: Uncontrolled inflammation is a major pathological factor underlying a range of diseases including autoimmune conditions, cardiovascular disease, and cancer. Improving localized delivery of immunosuppressive drugs to inflamed tissue in a non-invasive manner offers significant promise… read more here.
Keywords: skeletal muscle; loaded liposomes; inflamed skeletal; delivery ... See more keywords
Bioengineered 3D Skeletal Muscle Model Reveals Complement 4b as a Cell‐Autonomous Mechanism of Impaired Regeneration with Aging
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Materials"
DOI: 10.1002/adma.202207443
Abstract: A mechanistic understanding of cell‐autonomous skeletal muscle changes after injury can lead to novel interventions to improve functional recovery in an aged population. However, major knowledge gaps persist owing to limitations of traditional biological aging… read more here.
Keywords: regeneration; bioengineered skeletal; cell autonomous; muscle ... See more keywords
Skeletal Muscle Fibers Inspired Polymeric Actuator by Assembly of Triblock Polymers
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202105764
Abstract: Inspired by the striated structure of skeletal muscle fibers, a polymeric actuator by assembling two symmetric triblock copolymers, namely, polystyrene‐b‐poly(acrylic acid)‐b‐polystyrene (SAS) and polystyrene‐b‐poly(ethylene oxide)‐b‐polystyrene (SES) is developed. Owing to the microphase separation of the… read more here.
Keywords: muscle; muscle fibers; polymeric actuator; skeletal muscle ... See more keywords
Emerging role of TAK1 in the regulation of skeletal muscle mass
Sign Up to like & getrecommendations! Published in 2023 at "BioEssays"
DOI: 10.1002/bies.202300003
Abstract: Maintenance of skeletal muscle mass and strength throughout life is crucial for heathy living and longevity. Several signaling pathways have been implicated in the regulation of skeletal muscle mass in adults. TGF‐β‐activated kinase 1 (TAK1)… read more here.
Keywords: regulation skeletal; muscle; tak1; skeletal muscle ... See more keywords