Tackling the Spiro Tetracyclic Skeleton of Cyanogramide: Incorporation of a Hydantoin Moiety.
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DOI: 10.1021/acs.orglett.8b03540
Abstract: Wang's enantioselective thiourea-catalyzed spiro-annulation paved the way to the first tetracyclic analog of the marine natural product cyanogramide from the actinobacterium Actinoalloteichus cyanogriseus. The synthesis comprises seven steps starting from an alkylidene indolinone. Installation of… read more here.
Keywords: spiro tetracyclic; skeleton cyanogramide; hydantoin; tackling spiro ... See more keywords