Echinocystic Acid Ameliorates Arthritis in SKG Mice by Suppressing Th17 Cell Differentiation and Human Rheumatoid Arthritis Fibroblast-Like Synoviocytes Inflammation.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c05802
Abstract: Echinocystic acid (EA), a pentacyclic triterpene, exhibits anti-inflammatory, antioxidant, and analgesic activities to counteract pathological effects in various diseases. Here, we aimed to determine the immunomodulatory effect of EA on zymosan-induced arthritis in SKG mice… read more here.
Keywords: arthritis; skg mice; differentiation; cell differentiation ... See more keywords
Persistent articular infection and host reactive response contribute to Brucella-induced spondyloarthritis in SKG mice
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DOI: 10.1128/mbio.00542-25
Abstract: ABSTRACT Brucellosis, one of the most prevalent zoonotic diseases worldwide, often results in osteoarticular complications including large joint and axial arthritis mimicking spondyloarthritis. To model this chronic manifestation, we infected autoimmunity-prone SKG mice containing a… read more here.
Keywords: skg mice; infection; brucella; arthritis ... See more keywords
IL-23 favours outgrowth of spondyloarthritis-associated pathobionts and suppresses host support for homeostatic microbiota
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2018-214381
Abstract: Objectives Certain gut bacterial families, including Bacteroidaceae, Porphyromonadaceae and Prevotellaceae, are increased in people suffering from spondyloarthropathy (SpA), a disease group associated with IL23R signalling variants. To understand the relationship between host interleukin (IL)-23 signalling… read more here.
Keywords: associated pathobionts; favours outgrowth; skg mice; disease ... See more keywords
STING-STAT6 Signaling Pathway Promotes IL-4+ and IFN-α+ Fibrotic T Cell Activation and Exacerbates Scleroderma in SKG Mice
Sign Up to like & getrecommendations! Published in 2024 at "Immune Network"
DOI: 10.4110/in.2024.24.e37
Abstract: Systemic sclerosis (SS) is an autoimmune disease and pathological mechanisms of SS are unclear. In this study, we investigated the role of T cells in the progression of SS using SKG mice and humanized mice.… read more here.
Keywords: mice; sting stat6; mouse model; scleroderma skg ... See more keywords