SKI and SMAD4 are essential for IL-21-induced Th17 differentiation.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular immunology"
DOI: 10.1016/j.molimm.2019.07.029
Abstract: Th17 cells are essential for the pathogenesis of inflammatory and autoimmune diseases. In the presence of TGF-β, the differentiation of Th17 cells can be induced by inflammatory cytokines, especially IL-6, which is mainly produced by… read more here.
Keywords: ski smad4; th17 differentiation; differentiation; induced th17 ... See more keywords
Releasing Ski-Smad4 mediated suppression is essential to license Th17 differentiation
Sign Up to like & getrecommendations! Published in 2017 at "Nature"
DOI: 10.1038/nature24283
Abstract: T helper 17 (TH17) cells are critically involved in host defence, inflammation, and autoimmunity. Transforming growth factor β (TGFβ) is instrumental in TH17 cell differentiation by cooperating with interleukin-6 (refs 6, 7). Yet, the mechanism… read more here.
Keywords: cell differentiation; differentiation; th17 cell; ski smad4 ... See more keywords