Chemopreventive effect of dieckol against 7,12‐dimethylbenz(a)anthracene induced skin carcinogenesis model by modulatory influence on biochemical and antioxidant biomarkers
Sign Up to like & getrecommendations! Published in 2020 at "Environmental Toxicology"
DOI: 10.1002/tox.23082
Abstract: Skin cancer is the commonly found type, which contributes to 40% of whole cancer incidences worldwide. Dieckol is an active compound occurs in the marine algae with many biological benefits. In this exploration, we intended… read more here.
Keywords: skin carcinogenesis; dieckol dimethylbenz; dieckol; dimethylbenz anthracene ... See more keywords
Suppression of the solar ultraviolet-induced skin carcinogenesis by TOPK inhibitor HI-TOPK-032
Sign Up to like & getrecommendations! Published in 2020 at "Oncogene"
DOI: 10.1038/s41388-020-1286-4
Abstract: Nonmelanoma skin cancer (NMSC) such as cutaneous squamous cell carcinoma (cSCC) is caused by solar ultraviolet (SUV) exposure and is the most common cancer in the United States. T-LAK cell-originated protein kinase (TOPK), a serine-threonine… read more here.
Keywords: solar ultraviolet; skin carcinogenesis; topk; induced skin ... See more keywords
The environmental carcinogen benzo[a]pyrene regulates epigenetic reprogramming and metabolic rewiring in a two-stage mouse skin carcinogenesis model.
Sign Up to like & getrecommendations! Published in 2023 at "Carcinogenesis"
DOI: 10.1093/carcin/bgad024
Abstract: Nonmelanoma skin cancer (NMSC) is the most common cancer in the world. Environmental exposure to carcinogens is one of the major causes of NMSC initiation and progression. In the current study, we utilized a two-stage… read more here.
Keywords: cancer; benzo pyrene; two stage; skin carcinogenesis ... See more keywords
Identification of Master Regulator Genes of UV Response and Their Implications for Skin Carcinogenesis.
Sign Up to like & getrecommendations! Published in 2018 at "Carcinogenesis"
DOI: 10.1093/carcin/bgy168
Abstract: Solar UV radiation is a major environmental risk factor for skin cancer. Despite decades of robust and meritorious investigation, our understanding of the mechanisms underlying UV-induced skin carcinogenesis remain incomplete. We previously performed comprehensive transcriptomic… read more here.
Keywords: master; identification master; skin carcinogenesis; carcinogenesis identification ... See more keywords
CENP‐50 is required for papilloma development in the two‐stage skin carcinogenesis model
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Science"
DOI: 10.1111/cas.14533
Abstract: CENP‐50/U is a component of the CENP‐O complex (CENP‐O/P/Q/R/U) and localizes to the centromere throughout the cell cycle. Aberrant expression of CENP‐50/U has been reported in many types of cancers. However, as Cenp‐50/U‐deficient mice die… read more here.
Keywords: skin carcinogenesis; papilloma development; cenp; mice ... See more keywords
Abstract 4650: TOPK is a prognostic marker and therapeutic target in skin carcinogenesis
Sign Up to like & getrecommendations! Published in 2019 at "Tumor Biology"
DOI: 10.1158/1538-7445.am2019-4650
Abstract: Solar ultraviolet (sUV) is linked to development of cutaneous squamous cell carcinoma (cSCC) as a non-melanoma skin cancer (NMSC). Actinic keratosis (AK), induced by sUV irradiation, acts as precursor to cutaneous squamous cell carcinoma (cSCC)… read more here.
Keywords: mice; skin; target; topk ... See more keywords
Abstract 6380: Suppression of the solar ultraviolet-induced skin carcinogenesis by TOPK inhibitor HI-TOPK-032
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.am2020-6380
Abstract: Non-melanoma skin cancer (NMSC) such as cutaneous squamous cell carcinoma (cSCC) is caused by solar ultraviolet (SUV) exposure and is the most common cancer in the United States. T-LAK cell-originated protein kinase (TOPK), a serine-threonine… read more here.
Keywords: solar ultraviolet; skin carcinogenesis; topk; cancer ... See more keywords
Itraconazole for Topical Treatment of Skin Carcinogenesis: Efficacy Enhancement by Lipid Nanocapsule Formulations.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of biomedical nanotechnology"
DOI: 10.1166/jbn.2022.3217
Abstract: Itraconazole (ITC), an antifungal drug with anticancer activity, shows potential for oral treatment of skin cancer. There is clinical need for topical ITC for treating low-risk skin carcinogenesis. Our objective was to develop ITC nanoformulations… read more here.
Keywords: itc lnc; nanotechnology; itc; treatment ... See more keywords
1,8-cineole prevents UVB-induced skin carcinogenesis by targeting the aryl hydrocarbon receptor
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.22519
Abstract: 1,8-cineole is a natural monoterpene cyclic ether present in Eucalyptus, and has been reported to exhibit anti-inflammatory and antioxidant effects. However, the preventive effect of 1,8-cineole on skin carcinogenesis and the molecular mechanism of action… read more here.
Keywords: skin carcinogenesis; induced skin; expression; uvb induced ... See more keywords
Gene Deletion of Microsomal Prostaglandin E Synthase-1 Suppresses Chemically Induced Skin Carcinogenesis
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DOI: 10.21873/anticanres.14888
Abstract: Background/Aim: Microsomal prostaglandin (PG) E synthase-1 (mPGES-1) is a terminal enzyme in PGE2 synthesis and highly expressed in several cancers. In this study, to reveal the involvement of mPGES-1 in skin carcinogenesis, the effect of… read more here.
Keywords: microsomal prostaglandin; skin carcinogenesis; prostaglandin synthase; induced skin ... See more keywords
Ultraviolet Radiation and Chronic Inflammation—Molecules and Mechanisms Involved in Skin Carcinogenesis: A Narrative Review
Sign Up to like & getrecommendations! Published in 2021 at "Life"
DOI: 10.3390/life11040326
Abstract: The process of skin carcinogenesis is still not fully understood. Both experimental and epidemiological evidence indicate that chronic inflammation is one of the hallmarks of microenvironmental-agent-mediated skin cancers and contributes to its development. Maintaining an… read more here.
Keywords: skin carcinogenesis; inflammation; chronic inflammation; ultraviolet radiation ... See more keywords