Loss‐of‐function mutations in CST6 cause dry skin, desquamation and abnormal keratosis without hypotrichosis
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DOI: 10.1111/cge.14265
Abstract: Cystatin M/E (encoded by the CST6 gene) is a cysteine protease inhibitor, that exerts regulatory and protective effects against uncontrolled proteolysis mainly by directly regulating cathepsin V, cathepsin L, and legumain activities. Previous studies have… read more here.
Keywords: function; skin; skin desquamation; dry skin ... See more keywords
Human Tissue Kallikreins-Related Peptidases Are Targets for the Treatment of Skin Desquamation Diseases
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DOI: 10.3389/fmed.2021.777619
Abstract: Human tissue Kallikrein-related peptidases (hKLKs) are serine proteases distributed in several tissues that are involved in several biological processes. In skin, many are responsible for skin desquamation in the Stratum Corneum (SC) of the epidermis,… read more here.
Keywords: skin desquamation; skin diseases; desquamation; related peptidases ... See more keywords