Endoglin haploinsufficiency is associated with differential regulation of extracellular matrix production during skin fibrosis and cartilage repair in mice
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cell Communication and Signaling"
DOI: 10.1007/s12079-018-0461-7
Abstract: Transforming growth factor (TGF)-β is a multifunctional growth factor with potent pro-fibrotic effects. Endoglin is a TGF-β co-receptor that strongly regulates TGF-β signaling in a variety of cell types. Although aberrant regulation of TGF-β signaling… read more here.
Keywords: mice; skin fibrosis; cartilage; endoglin haploinsufficiency ... See more keywords
Nrf2 in keratinocytes protects against skin fibrosis via regulating epidermal lesion and inflammatory response.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2020.113846
Abstract: Nuclear factor-E2-related factor 2 (Nrf2) is a master transcription factor in antioxidant response, protecting against oxidative damage and various diseases. Previous studies suggest that Nrf2 is suppressed in fibrotic skin and Nrf2 agonists represent a… read more here.
Keywords: fibrosis; response; skin fibrosis; keratinocytes protects ... See more keywords
Nanoparticle-mediated local delivery of pioglitazone attenuates bleomycin-induced skin fibrosis.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of dermatological science"
DOI: 10.1016/j.jdermsci.2018.11.012
Abstract: BACKGROUND Nanoparticle-loaded delivery systems have attracted much attention recently. Poly(lactic-co-glycolic acid) (PLGA) is one of the most successful biodegradable polymers for biomedical applications. There are only a few studies on the treatment of dermal fibrosis… read more here.
Keywords: cultured fibroblasts; fibrosis; pioglitazone; plga nanoparticles ... See more keywords
IL-25 participates in keratinocyte-driven dermal matrix turnover and is reduced in Systemic Sclerosis epidermis.
Sign Up to like & getrecommendations! Published in 2022 at "Rheumatology"
DOI: 10.1093/rheumatology/keac044
Abstract: OBJECTIVES Evidence shows that dysfunctional SSc keratinocytes contribute to fibrosis by altering dermal homeostasis. Whether interleukin-25 (IL-25), an IL-17 family member regulating many epidermal functions, takes part in skin fibrosis is unknown. Here we address… read more here.
Keywords: keratinocyte driven; skin fibrosis; ssc; participates keratinocyte ... See more keywords
Role of STAT3 in skin fibrosis and transforming growth factor beta signalling
Sign Up to like & getrecommendations! Published in 2018 at "Rheumatology"
DOI: 10.1093/rheumatology/kex347
Abstract: Objective SSc is an autoimmune disease characterized by progressive fibrosis of the skin and internal organs. IL-6 and related cytokines that signal through STAT3 have been implicated in the pathogenesis of SSc and mouse models… read more here.
Keywords: mouse models; fibrosis; role stat3; stat3 ... See more keywords
The Combination of Resveratrol and High-Fluence Light Emitting Diode-Red Light Produces Synergistic Photobotanical Inhibition of Fibroblast Proliferation and Collagen Synthesis: A Novel Treatment for Skin Fibrosis
Sign Up to like & getrecommendations! Published in 2017 at "Dermatologic Surgery"
DOI: 10.1097/dss.0000000000000921
Abstract: BACKGROUND Skin fibrosis is a debilitating condition that significantly impacts patient quality of life. Ultraviolet phototherapy is currently used to treat several diseases featuring skin fibrosis. High-fluence light-emitting diode–generated red light (HF-LED-RL) does not cause… read more here.
Keywords: fibroblast proliferation; proliferation; light; skin fibrosis ... See more keywords
Transforming growth factor β‐inhibitor Repsox downregulates collagen expression of scleroderma dermal fibroblasts and prevents bleomycin‐induced mice skin fibrosis
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Dermatology"
DOI: 10.1111/exd.13366
Abstract: Inhibition of transforming growth factor (TGF)‐β1 signalling may be one of the most reliable approaches to treat skin fibrosis of scleroderma. Although there have been many basic researches of TGF‐β blockade reagents, few of them… read more here.
Keywords: transforming growth; fibrosis; repsox; growth factor ... See more keywords
OP0036 Serological biomarkers of ecm turnover are associated with skin fibrosis and lung involvement in systemic sclerosis
Sign Up to like & getrecommendations! Published in 2017 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2017-eular.4855
Abstract: Background Extracellular matrix (ECM) unbalance of the skin is a hallmark of systemic sclerosis (SSc). However, currently there is no objective tool to monitor the ECM unbalance in SSc patients allowing for better understanding of… read more here.
Keywords: skin fibrosis; ssc patients; involvement; serological biomarkers ... See more keywords
THU0336 DEVELOPING A NOVEL RAPID EX VIVO MODEL OF SKIN FIBROSIS FOR SYSTEMIC SCLEROSIS RESEARCH
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2019-eular.1881
Abstract: Background Systemic Sclerosis (SSc) is an autoimmune disease that causes tissue fibrosis in multiple systems. Immune dysfunction and dysregulation are known to play a role in the disease, but the pathophysiology of SSc is not… read more here.
Keywords: collagen; fibrosis; vivo model; skin fibrosis ... See more keywords
Deep Proteome Profiling Reveals Common Prevalence of MZB1‐Positive Plasma B Cells in Human Lung and Skin Fibrosis
Sign Up to like & getrecommendations! Published in 2017 at "American Journal of Respiratory and Critical Care Medicine"
DOI: 10.1164/rccm.201611-2263oc
Abstract: Rationale: Analyzing the molecular heterogeneity of different forms of organ fibrosis may reveal common and specific factors and thus identify potential future therapeutic targets. Objectives: We sought to use proteome‐wide profiling of human tissue fibrosis… read more here.
Keywords: fibrosis; lung skin; skin fibrosis; plasma cells ... See more keywords
PAI1 mediates fibroblast–mast cell interactions in skin fibrosis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Investigation"
DOI: 10.1172/jci99088
Abstract: Fibrosis is a prevalent pathological condition arising from the chronic activation of fibroblasts. This activation results from the extensive intercellular crosstalk mediated by both soluble factors and direct cell-cell connections. Prominent among these are the… read more here.
Keywords: mast; skin fibrosis; fibroblast mast; mast cell ... See more keywords