Reprogramming of Fatty Acid Metabolism via PPARα‐Orchestrated FADS2 in Keratinocytes Modulates Skin Inflammation in Psoriasis
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202417049
Abstract: Psoriasis is a chronic inflammatory skin disorder characterized by keratinocyte hyper‐proliferation and immune dysregulation. Recent evidence has implicated dysregulated polyunsaturated fatty acid (PUFA) metabolism in its pathogenesis. In this study, fatty acid desaturase 2 (FADS2),… read more here.
Keywords: metabolism; skin inflammation; inflammation; fads2 ... See more keywords
Unraveling the Curcumin's Molecular Targets and Its Potential in Suppressing Skin Inflammation Using Network Pharmacology and In Vitro Studies
Sign Up to like & getrecommendations! Published in 2025 at "Drug Development Research"
DOI: 10.1002/ddr.70058
Abstract: Curcumin, a polyphenol compound derived from turmeric, has garnered attention for its anti‐inflammatory and antioxidant properties, making it a promising candidate for treating skin inflammation. Despite its potential, the underlying pharmacological effects to skin inflammation… read more here.
Keywords: pharmacology; vitro; inflammation; curcumin ... See more keywords
The effects of galectin‐3 depletion apheresis on induced skin inflammation in a porcine model
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Apheresis"
DOI: 10.1002/jca.21624
Abstract: Galectin‐3 (Gal‐3), a β‐galactoside‐binding lectin that is expressed in mammalian cells, is known to modulate several biological functions such as cell‐cell adhesion, macrophage activation, angiogenesis, metastasis, and fibrosis. The goal of this study was to… read more here.
Keywords: inflammation porcine; depletion apheresis; inflammation; apheresis ... See more keywords
Hapten-Specific T Cell-Mediated Skin Inflammation: Flow Cytometry Analysis of Mouse Skin Inflammatory Infiltrate.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6786-5_2
Abstract: Hapten-specific T cell-mediated skin inflammation also known as contact hypersensitivity (CHS) is characterized by a strong influx of CD8+ cytotoxic T cells within the skin upon reexposure of sensitized individuals to the same hapten. As… read more here.
Keywords: mediated skin; cell mediated; specific cell; hapten specific ... See more keywords
Star fruit extract and C-glycosylated flavonoid components have potential to prevent air pollutant-induced skin inflammation and premature aging
Sign Up to like & getrecommendations! Published in 2022 at "Natural Products and Bioprospecting"
DOI: 10.1007/s13659-022-00336-1
Abstract: Air pollution adversely affects skin, leading to skin inflammation and premature skin aging. Plant derived antioxidant compounds have been considered to be promising in discovery of effective agents for the protection of skin from the… read more here.
Keywords: skin inflammation; air; star fruit; inflammation ... See more keywords
MicroRNA-124 alleviates chronic skin inflammation in atopic eczema via suppressing innate immune responses in keratinocytes.
Sign Up to like & getrecommendations! Published in 2017 at "Cellular immunology"
DOI: 10.1016/j.cellimm.2017.08.003
Abstract: Chronic skin inflammation in atopic eczema is associated with elevated expression of proinflammatory genes and activation of innate immune responses in keratinocytes. MicroRNAs (miRNAs) are short, single-stranded RNA molecules that silence genes via the degradation… read more here.
Keywords: mir 124; atopic eczema; skin inflammation;
Allergic skin inflammation and S. aureus skin colonization are mutually reinforcing.
Sign Up to like & getrecommendations! Published in 2020 at "Clinical immunology"
DOI: 10.1016/j.clim.2020.108511
Abstract: Atopic dermatitis (AD) lesional skin is often colonized with S. aureus, and the load of S. aureus correlates with disease severity. However, a causative and mechanistic link between S. aureus skin colonization and severity of… read more here.
Keywords: skin inflammation; colonization; allergic skin; aureus skin ... See more keywords
APRIL expression is upregulated in atopic dermatitis skin lesions and at sites of antigen driven allergic skin inflammation in mice.
Sign Up to like & getrecommendations! Published in 2020 at "Clinical immunology"
DOI: 10.1016/j.clim.2020.108556
Abstract: Atopic dermatitis (AD) is the most common inflammatory skin disease. It is characterized by a defective skin barrier and a Th2 dominated skin inflammation. The TNF family member a proliferation-inducing ligand (APRIL) and its receptors… read more here.
Keywords: inflammation; skin; atopic dermatitis; april expression ... See more keywords
Gasdermin E mediates pyroptotic cell death of neutrophils and macrophages in a zebrafish model of chronic skin inflammation.
Sign Up to like & getrecommendations! Published in 2022 at "Developmental and comparative immunology"
DOI: 10.1016/j.dci.2022.104404
Abstract: Chronic disease and hematopoietic disorders are associated with dysregulation of the inflammasome. Our group has recently reported the relevance of the inflammasome in the differentiation of hematopoietic stem and progenitor cells. However, the impact of… read more here.
Keywords: gasdermin; zebrafish model; skin inflammation; death ... See more keywords
Mangiferin antagonizes TNF‐&agr;‐mediated inflammatory reaction and protects against dermatitis in a mice model
Sign Up to like & getrecommendations! Published in 2017 at "International Immunopharmacology"
DOI: 10.1016/j.intimp.2017.02.014
Abstract: &NA; This study aimed to investigate whether mangiferin played a protective role in a well‐established dermatitis mouse model and tumor necrosis factor alpha (TNF‐&agr;)‐induced RAW264.7 macrophages. Contact dermatitis is an inflammatory skin disease in the… read more here.
Keywords: inflammatory reaction; tnf agr; inflammation; dermatitis mice ... See more keywords
Inhibitory Effect of Quercetin on Propionibacterium acnes-induced Skin Inflammation.
Sign Up to like & getrecommendations! Published in 2021 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2021.107557
Abstract: Quercetin is a well-known antioxidant and a plant polyphenolic of flavonoid group found in many fruits, leaves, and vegetables. Propionibacterium acnes is a key skin pathogen involved in the progression of acne inflammation. Although quercetin… read more here.
Keywords: propionibacterium acnes; inflammation; skin inflammation; induced skin ... See more keywords