Induced antibodies directed to the angiotensin receptor type 1 provoke skin and lung inflammation, dermal fibrosis and act species overarching
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DOI: 10.1136/annrheumdis-2021-222088
Abstract: Objective To determine contributions and functions of autoantibodies (Abs) directed to the angiotensin receptor type 1 (AT1R), which are suggested to be involved in the pathogenesis of AT1R Abs-related diseases such as systemic sclerosis (SSc).… read more here.
Keywords: lung; lung inflammation; skin lung; at1r ... See more keywords
PLG nanoparticles target fibroblasts and MARCO+ monocytes to reverse multiorgan fibrosis
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DOI: 10.1172/jci.insight.151037
Abstract: Systemic sclerosis (SSc) is a chronic, multisystem orphan disease with a highly variable clinical course, high mortality rate, and a poorly understood complex pathogenesis. We have identified an important role for a subpopulation of monocytes… read more here.
Keywords: marco monocytes; skin lung; plg nanoparticles; nanoparticles target ... See more keywords
Increased Complement Activation in Systemic Sclerosis Patients with Skin and Lung Fibrosis
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DOI: 10.3390/jpm12020284
Abstract: Introduction: The involvement of complement system in the phenotypic expression of systemic sclerosis (SSc) is a debated topic. We aimed to assay complement fractions in SSc patients and to correlate their levels with the clinical… read more here.
Keywords: lung fibrosis; ssc patients; skin lung; ch50 ... See more keywords