Methylquercetins stimulate melanin biosynthesis in a three-dimensional skin model
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Natural Medicines"
DOI: 10.1007/s11418-018-1175-0
Abstract: In a previous study, we found that both synthetic 3-O-methylquercetin (3MQ) and 3,4′,7-O-trimethylquercetin (34′7TMQ) increased extracellular melanin content. 34′7TMQ increased the activity of melanogenic enzymes by stimulating the p38 pathway and the expression of microphthalmia-associated… read more here.
Keywords: three dimensional; dimensional skin; melanin; model ... See more keywords
Innovative Surface Merging Method for Generating Point-Based Skin Model Shapes Considering Processing Features
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Precision Engineering and Manufacturing"
DOI: 10.1007/s12541-020-00396-8
Abstract: Virtual prototypes have been appealing in the early design stage of computer aided tolerancing, because it is less expensive to evaluate and modify tolerances numerically. Derived from the machining processes, form uncertainties are simulated, controlled… read more here.
Keywords: skin model; surface; method; surface merging ... See more keywords
Tribological interactions of 3D printed polyurethane and polyamide with water-responsive skin model
Sign Up to like & getrecommendations! Published in 2021 at "Friction"
DOI: 10.1007/s40544-020-0472-2
Abstract: 3D printing in the textile and fashion industry is a new emerging technology. Applications of 3D printing for designing clothes and other wearable accessories require tribological and biological understanding of 3D printing plastics against the… read more here.
Keywords: responsive skin; skin model; water responsive; friction ... See more keywords
Development of a 3D psoriatic skin model optimized for infiltration of IL-17A producing T cells: focus on the crosstalk between T cells and psoriatic keratinocytes.
Sign Up to like & getrecommendations! Published in 2021 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2021.09.018
Abstract: Psoriasis is a chronic inflammatory skin disease involving several cell types, including T cells, via the IL-23/IL-17 axis. IL-17A acts on the surrounding epithelial cells thus resulting in an inflammatory feedback loop. The development of… read more here.
Keywords: psoriatic skin; model; cells psoriatic; skin model ... See more keywords
A new ex vivo skin model for mechanistic understanding of putative anti-inflammatory topical therapeutics.
Sign Up to like & getrecommendations! Published in 2022 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2022.121610
Abstract: Several in vitro models have been designed as test systems for inflammatory skin conditions, commonly using cell-culture or reconstructed human epidermis approaches. However, these systems poorly recapitulate the physiology and, importantly, the metabolism and biochemical… read more here.
Keywords: vivo skin; model mechanistic; skin model; model ... See more keywords
Establishment of a novel in vitro viable human skin model as a basis for the treatment of human and veterinary chronic skin diseases
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Drug Delivery Science and Technology"
DOI: 10.1016/j.jddst.2019.04.008
Abstract: Abstract Transdermal drug delivery avoids first-pass metabolism and provides decreased toxicity risk and higher patient compliance compared to gastrointestinal drug administration. Drug development may be significantly shortened by transfer from in vivo to in vitro… read more here.
Keywords: skin model; drug; skin; vitro ... See more keywords
Liposomogenic UV Absorbers are Water-Resistant on Pig Skin-A Model Study With Relevance for Sunscreens.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2016.09.031
Abstract: An important property of sunscreens is their water resistance after the application on human skin. In this work, the hypothesis that UV absorber molecules which are able to form liposomes, so-called liposomogenic UV absorbers, show better… read more here.
Keywords: water; skin model; liposomogenic absorbers; pig skin ... See more keywords
Fish Gelatin-Hyaluronic Acid Scaffold for Construction of an Artificial Three-Dimensional Skin Model
Sign Up to like & getrecommendations! Published in 2025 at "ACS Omega"
DOI: 10.1021/acsomega.4c09708
Abstract: Artificial three-dimensional (3D) skin models have been used as an alternative tool for toxicity testing, skin disease studying, and skin tissue engineering. The 3D skin model can be fabricated using a porous scaffold that provides… read more here.
Keywords: artificial three; skin model; three dimensional; skin ... See more keywords
A human ex vivo skin model breaking boundaries
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-75291-7
Abstract: Ex vivo human skin models are valuable tools in skin research due to their physiological relevance. Traditionally, standard cultivation is performed in a cell culture incubator with a defined temperature of 37 °C and a… read more here.
Keywords: vivo skin; skin model; culture; model ... See more keywords
Culture insert device with perfusable microchannels enhances in vitro skin model development and barrier function assessment
Sign Up to like & getrecommendations! Published in 2024 at "Biofabrication"
DOI: 10.1088/1758-5090/ad3a15
Abstract: The ever-stricter regulations on animal experiments in the field of cosmetic testing have prompted a surge in skin-related research with a special focus on recapitulation of the in vivo skin structure in vitro. In vitro… read more here.
Keywords: device; vitro skin; skin model; culture ... See more keywords
Towards the development of a RNAi‐based topical treatment for psoriasis: Proof‐of‐concept in a 3D psoriasis skin model
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Dermatology"
DOI: 10.1111/exd.13414
Abstract: RNA interference has emerged as a powerful tool for therapeutic gene silencing, as it offers the possibility to silence virtually any known pathology‐causing gene. However, in vivo delivery of RNAi molecules is hampered by their… read more here.
Keywords: treatment; rnai; treatment psoriasis; topical treatment ... See more keywords