Patient‐derived in vitro skin models for investigation of small fiber pathology
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.50871
Abstract: To establish individually expandable primary fibroblast and keratinocyte cultures from 3‐mm skin punch biopsies for patient‐derived in vitro skin models to investigate of small fiber pathology. read more here.
Keywords: derived vitro; skin models; vitro skin; small fiber ... See more keywords
Skin Disease Models In Vitro and Inflammatory Mechanisms: Predictability for Drug Development.
Sign Up to like & getrecommendations! Published in 2021 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2020_428
Abstract: Investigative skin biology, analysis of human skin diseases, and numerous clinical and pharmaceutical applications rely on skin models characterized by reproducibility and predictability. Traditionally, such models include animal models, mainly rodents, and cellular models. While… read more here.
Keywords: skin models; skin; drug; biology ... See more keywords
Xenobiotica-metabolizing enzymes in the skin of rat, mouse, pig, guinea pig, man, and in human skin models
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Toxicology"
DOI: 10.1007/s00204-018-2232-x
Abstract: Studies on the metabolic fate of medical drugs, skin care products, cosmetics and other chemicals intentionally or accidently applied to the human skin have become increasingly important in order to ascertain pharmacological effectiveness and to… read more here.
Keywords: pig; xenobiotica metabolizing; skin models; skin ... See more keywords
Comparison Between Franz Diffusion Cell and a novel Micro-physiological System for In Vitro Penetration Assay Using Different Skin Models.
Sign Up to like & getrecommendations! Published in 2022 at "SLAS technology"
DOI: 10.1016/j.slast.2021.12.006
Abstract: In vitro diffusive models are an important tool to screen the penetration ability of active ingredients in various formulations. A reliable assessment of skin penetration enhancing properties, mechanism of action of carrier systems, and an… read more here.
Keywords: franz diffusion; penetration; skin models; diffusion cell ... See more keywords
Standalone single- and bi-layered human skin 3D models supported by recombinant silk feature native spatial organization
Sign Up to like & getrecommendations! Published in 2024 at "Biofabrication"
DOI: 10.1088/1758-5090/ad8b72
Abstract: Physiologically relevant human skin models that include key skin cell types can be used for in vitro drug testing, skin pathology studies, or clinical applications such as skin grafts. However, there is still no golden… read more here.
Keywords: human skin; silk; standalone single; skin models ... See more keywords
Cerium nitrate stiffens in-vitro skin models and reduces Pseudomonas aeruginosa pathogenicity and penetration through skin models.
Sign Up to like & getrecommendations! Published in 2022 at "Advances in wound care"
DOI: 10.1089/wound.2022.0026
Abstract: OBJECTIVE Cerium nitrate (CeN) plus silver sulfadiazine (SSD) cream has been used for 40-plus years to manage burns. CeN produces a hardened eschar believed to resist bacterial colonization/infection. To evaluate this potential mechanism, we treated… read more here.
Keywords: skin models; skin; vitro skin; penetration ... See more keywords
Skin microbiota and human 3D skin models
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Dermatology"
DOI: 10.1111/exd.13517
Abstract: Although the role of the microbiota in skin homeostasis is still emerging, there is growing evidence that an intact microbiota supports the skin barrier. The increasing number of research efforts that are trying to shed… read more here.
Keywords: skin models; skin; human skin; microbiota human ... See more keywords
3D skin models in domestic animals
Sign Up to like & getrecommendations! Published in 2021 at "Veterinary Research"
DOI: 10.1186/s13567-020-00888-5
Abstract: The skin is a passive and active barrier which protects the body from the environment. Its health is essential for the accomplishment of this role. Since several decades, the skin has aroused a strong interest… read more here.
Keywords: skin models; domestic animals; pharmacology; cosmetology ... See more keywords
Implementing differentially pigmented skin models for predicting drug response variability across human ancestries
Sign Up to like & getrecommendations! Published in 2024 at "Human Genomics"
DOI: 10.1186/s40246-024-00677-7
Abstract: Persistent racial disparities in health outcomes have catalyzed legislative reforms and heightened scientific focus recently. However, despite the well-documented properties of skin pigments in binding drug compounds, their impact on therapeutic efficacy and adverse drug… read more here.
Keywords: differentially pigmented; skin models; implementing differentially; pigmented skin ... See more keywords
Radiation-induced alterations in multi-layered, in-vitro skin models detected by optical coherence tomography and histological methods
Sign Up to like & getrecommendations! Published in 2023 at "PLOS ONE"
DOI: 10.1371/journal.pone.0281662
Abstract: Background Inflammatory skin reactions and skin alterations are still a potential side effect in radiation therapy (RT), which also need attention for patients’ health care. Method In a pre-clinical study we consider alterations in irradiated… read more here.
Keywords: skin models; skin; vitro skin; coherence tomography ... See more keywords
Development of pathological skin models: from conventional techniques to 3D bioprinting
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2025.1538774
Abstract: Reconstructed human skin models were first developed in the 1970s. Since then, they have played a pivotal role in dermatological research, significantly advanced our understanding of skin biology, and brought huge insights into dermatological pathologies.… read more here.
Keywords: skin models; pathological skin; conventional techniques; development pathological ... See more keywords