Quantitative structure-skin permeability relationships.
Sign Up to like & getrecommendations! Published in 2017 at "Toxicology"
DOI: 10.1016/j.tox.2017.06.008
Abstract: This paper reviews in silico models currently available for the prediction of skin permeability. A comprehensive discussion on the developed methods is presented, focusing on quantitative structure-permeability relationships. In addition, the mechanistic models and comparative… read more here.
Keywords: permeability; permeability relationships; skin permeability; quantitative structure ... See more keywords
Correlation between the structure and skin permeability of compounds
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-89587-5
Abstract: A three-descriptor quantitative structure–activity/toxicity relationship (QSAR/QSTR) model was developed for the skin permeability of a sufficiently large data set consisting of 274 compounds, by applying support vector machine (SVM) together with genetic algorithm. The optimal… read more here.
Keywords: model; correlation structure; skin permeability; svm ... See more keywords
Skin permeability, a dismissed necessity for anti‐wrinkle peptide performance
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Cosmetic Science"
DOI: 10.1111/ics.12770
Abstract: The skin offers various benefits and potential for peptide delivery if its barrier performance can be reduced temporarily and reversibly. As peptides possess high molecular weight, hydrophilic nature (in most cases), and ionizable groups in… read more here.
Keywords: skin; skin permeability; anti wrinkle; permeability dismissed ... See more keywords
RP-18 TLC and Computational Descriptors of Skin Permeability of Sunscreens
Sign Up to like & getrecommendations! Published in 2022 at "Skin Pharmacology and Physiology"
DOI: 10.1159/000522366
Abstract: The relationships between the reversed-phase thin layer chromatographic retention parameters obtained on octadecyl-modified silica (RP-18) sorbent for mobile phases containing water and one of six water-miscible organic modifiers (acetone, methanol, acetonitrile, tetrahydrofurane, N,N-dimethylformamide, 1,4-dioxane) and… read more here.
Keywords: skin permeability; descriptors skin; computational descriptors; tlc computational ... See more keywords
Development and evaluation of two-parameter linear free energy models for the prediction of human skin permeability coefficient of neutral organic chemicals
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cheminformatics"
DOI: 10.1186/s13321-021-00503-5
Abstract: The experimental values of skin permeability coefficients, required for dermal exposure assessment, are not readily available for many chemicals. The existing estimation approaches are either less accurate or require many parameters that are not readily… read more here.
Keywords: neutral organic; skin permeability; permeability; model ... See more keywords
Epidermal epidemic: unravelling the pathogenesis of chytridiomycosis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Experimental Biology"
DOI: 10.1242/jeb.191817
Abstract: ABSTRACT Chytridiomycosis, a lethal fungal skin disease of amphibians, fatally disrupts ionic and osmotic homeostasis. Infected amphibians increase their skin shedding rate (sloughing) to slow pathogen growth, but the sloughing process also increases skin permeability.… read more here.
Keywords: skin permeability; chytridiomycosis; epidermal epidemic; skin ... See more keywords
In Silico Prediction of Skin Permeability Using a Two-QSAR Approach
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14050961
Abstract: Topical and transdermal drug delivery is an effective, safe, and preferred route of drug administration. As such, skin permeability is one of the critical parameters that should be taken into consideration in the process of… read more here.
Keywords: two qsar; skin permeability; silico prediction; permeability ... See more keywords