Enhancement of Skin Permeation of a Hydrophilic Drug from Acryl-Based Pressure-Sensitive Adhesive Tape.
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceutical research"
DOI: 10.1007/s11095-021-02996-z
Abstract: PURPOSE Penetration enhancers are necessary to overcome a formidable barrier function of the stratum corneum in the development of topical formulations. Recently, non-lamella liquid crystal (NLLC)-forming lipids such as glycerol monooleate and phytantriol (PHY) are… read more here.
Keywords: hydrophilic drug; permeation; mge; skin permeation ... See more keywords
Enhanced skin permeation of glabridin using eutectic mixture-based nanoemulsion
Sign Up to like & getrecommendations! Published in 2017 at "Drug Delivery and Translational Research"
DOI: 10.1007/s13346-017-0359-6
Abstract: This study aimed to investigate the performance of the eutectic mixture of menthol and camphor (1:1, w/w) in nanoemulsion formulation for enhanced transdermal penetration of water-insoluble glabridin. Glabridin solubility in different media was determined by… read more here.
Keywords: nanoemulsion; skin permeation; eutectic mixture; mixture ... See more keywords
Enhanced vitamin C skin permeation from supramolecular hydrogels, illustrated using in situ ToF‐SIMS 3D chemical profiling
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Pharmaceutics"
DOI: 10.1016/j.ijpharm.2019.03.028
Abstract: Graphical abstract Figure. No caption available. ABSTRACT Vitamin C (ascorbic acid) is a naturally occurring, powerful anti‐oxidant with the potential to deliver numerous benefits to the skin when applied topically. However, topical use of this… read more here.
Keywords: analysis; tof sims; tof; skin permeation ... See more keywords
Quality by Design driven Development of Resveratrol Loaded Ethosomal hydrogel for Improved Dermatological Benefits via Enhanced Skin Permeation and Retention.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2019.118448
Abstract: Resveratrol is a potent anti oxidant agent and can be used for the effective management of different skin conditions like extrinsic skin ageing, psoriasis, etc. The objective of this research was to develop a dermal… read more here.
Keywords: ethosomal hydrogel; resveratrol; skin permeation; design ... See more keywords
Cubic Liquid Crystalline Structures in Diluted, Concentrated and Highly Concentrated Emulsions for Topical Application: Influence on Drug Release and Human Skin Permeation.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2019.118531
Abstract: Novel emulsions with a nanostructured continuous phase have been proposed as controlled drug delivery systems to enhance topical delivery of active ingredients avoiding systemic effects. In this study, oil-in-water (O/W) emulsions with two surfactant/water (S/W)… read more here.
Keywords: crystalline structures; rheology; drug; drug release ... See more keywords
Prediction of skin permeation and concentration of rhododendrol applied as finite dose from complex cosmetic vehicles.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2020.119186
Abstract: Finite dose experiments represent clinical use wherein depletion of dose, evaporation of excipients, and gradual change in vehicle composition may occur. In the present study, we attempted a mathematical approach for predicting skin permeation and… read more here.
Keywords: permeation concentration; permeation; finite dose; applied finite ... See more keywords
Monoacyl-phospatidylcholine nanostructured lipid carriers: Influence of lipid and surfactant content on in vitro skin permeation of flufenamic acid and fluconazole
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Drug Delivery Science and Technology"
DOI: 10.1016/j.jddst.2017.08.016
Abstract: Abstract Monoacyl-phosphatidylcholine (MAPL) is a skin-friendly phospholipid emulsifier that has successfully been employed for development of microemulsions. Its potential for stabilising particulate lipid drug carriers has not been explored so far. Thus, the aim of… read more here.
Keywords: content; skin permeation; vitro; flufenamic acid ... See more keywords
Simulating the Skin Permeation Process of Ionizable Molecules
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DOI: 10.1021/acs.jcim.4c00722
Abstract: It is commonly assumed that ionizable molecules, such as drugs, permeate through the skin barrier in their neutral form. By using molecular dynamics simulations of the charged and neutral states separately, we can study the… read more here.
Keywords: permeation process; simulating skin; ionizable molecules; skin permeation ... See more keywords
Mechanistic Modeling of In Vitro Skin Permeation and Extrapolation to In Vivo for Topically Applied Metronidazole Drug Products Using a Physiologically Based Pharmacokinetic Model.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00229
Abstract: Physiologically based pharmacokinetic (PBPK) modeling has increasingly been employed in dermal drug development and regulatory assessment, providing a framework to integrate relevant information including drug and drug product attributes, skin physiology parameters, and population variability.… read more here.
Keywords: skin permeation; stratum corneum; vitro skin; model ... See more keywords
Chromatographic Method for Determining 6‑Mercaptopurine in Skin Permeation Assays for Assessing Cutaneous Exposure Risk
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DOI: 10.1021/acsomega.5c04686
Abstract: 6-Mercaptopurine monohydrate (6-MP) is a drug often used in leukemia chemotherapy, but limited information is available about its cutaneous absorption, which raises concerns about occupational risks for healthcare professionals and caregivers. This study aimed to… read more here.
Keywords: method; permeation; risk; drug ... See more keywords
Hexagonal liquid crystalline system containing cinnamaldehyde for enhancement of skin permeation of sinomenine hydrochloride
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutical Development and Technology"
DOI: 10.1080/10837450.2022.2107011
Abstract: Abstract Sinomenine hydrochloride (SH) is usually applied to treat rheumatoid arthritis (RA) with severe side effects due to oral administration. Cinnamaldehyde (CA) as essential oil possesses an anti-RA effect and can facilitate transdermal penetration. Hence,… read more here.
Keywords: skin permeation; microscopy; sinomenine hydrochloride; permeation ... See more keywords