What determines skin sensitization potency: Myths, maybes and realities. The 500 molecular weight cut‐off: An updated analysis
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.3348
Abstract: It is widely accepted that substances must have a molecular weight (MW) < 500 to penetrate effectively through the skin to induce sensitization. Roberts et al. (2012. Contact Dermatitis 68: 32–41) evaluated a data set… read more here.
Keywords: updated analysis; chemistry; skin sensitization; molecular weight ... See more keywords
In Silico Models for Skin Sensitization and Irritation.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1960-5_13
Abstract: The assessment of skin irritation, and in particular of skin sensitization, has undergone an evolution process over the last years, pushing forward to new heights of quality and innovation. Public and commercial in silico tools… read more here.
Keywords: sensitization irritation; skin sensitization; sensitization; risk assessment ... See more keywords
Evaluation of in vitro assays for the assessment of the skin sensitization hazard of functional polysiloxanes and silanes
Sign Up to like & getrecommendations! Published in 2017 at "Regulatory Toxicology and Pharmacology"
DOI: 10.1016/j.yrtph.2016.12.009
Abstract: Abstract The skin sensitization potential of chemicals has traditionally been evaluated in vivo according to OECD testing guidelines in guinea pigs or the mouse local lymph node assay. There has lately been a great emphasis… read more here.
Keywords: evaluation vitro; sensitization; skin sensitization; polysiloxanes silanes ... See more keywords
Probabilistic derivation of the interspecies assessment factor for skin sensitization
Sign Up to like & getrecommendations! Published in 2017 at "Regulatory Toxicology and Pharmacology"
DOI: 10.1016/j.yrtph.2017.05.015
Abstract: ABSTRACT An interspecies sensitization assessment factor (SAF) is used in the quantitative risk assessment (QRA) for skin sensitization when a murine‐based NESIL (No Expected Sensitization Induction Level) is taken as point of departure. Several studies… read more here.
Keywords: assessment factor; skin sensitization; sensitization threshold; interspecies saf ... See more keywords
Pred-Skin: A web portal for accurate prediction of human skin sensitizers.
Sign Up to like & getrecommendations! Published in 2020 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.0c00186
Abstract: Safety assessment is an essential component of the regulatory acceptance of industrial chemicals. Previously we have developed a model to predict skin sensitization potential of chemicals for two assays, human patch test and murine local… read more here.
Keywords: pred skin; skin sensitization; skin; human skin ... See more keywords
Amino Reactivity of Glutardialdehyde and Monoaldehydes─Chemoassay Profile vs Skin Sensitization Potency.
Sign Up to like & getrecommendations! Published in 2021 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.1c00266
Abstract: Chemoassay profiling of organic electrophiles through the direct peptide reactivity assay has become an OECD-accepted nonanimal component in the REACH evaluation of potential skin sensitizers. For aldehydes forming imines (Schiff bases), however, existing chemoassays yielded… read more here.
Keywords: sensitization potency; reactivity; skin sensitization;
Theoretical Validation of In Chemico Skin Sensitization Assay "ADRA" Using the Products Formed by Nucleophilic Reagents and Chemicals.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.2c00228
Abstract: Amino acid derivative reactivity assay (ADRA) is an in chemico assay for assessing the skin sensitization potential of chemicals by evaluating the reactivity of nucleophilic reagents that mimic skin proteins. N-(2-(1-Naphthyl)acetyl)-l-cysteine (NAC) and α-N-(2-(1-naphthyl)acetyl)-l-lysine (NAL),… read more here.
Keywords: assay adra; skin; nucleophilic reagents; test ... See more keywords
The Good, The Bad, and The Perplexing: Structural Alerts and Read-Across for Predicting Skin Sensitization Using Human Data
Sign Up to like & getrecommendations! Published in 2023 at "Chemical Research in Toxicology"
DOI: 10.1021/acs.chemrestox.2c00383
Abstract: In our earlier work (Golden et al., 2021), we showed 70–80% accuracies for several skin sensitization computational tools using human data. Here, we expanded the data set using the NICEATM human skin sensitization database to… read more here.
Keywords: qsar toolbox; sensitization; oecd qsar; skin sensitization ... See more keywords
Reaction Chemistry to Characterize the Molecular Initiating Event in Skin Sensitization: A Journey to Be Continued.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.6b00365
Abstract: The publication by the OECD of the adverse outcome pathway (AOP) for skin sensitization has accelerated the development and validation of mechanistic tests and testing strategies to assess the potential of new molecules to trigger… read more here.
Keywords: skin sensitization; reaction chemistry; chemistry; reaction ... See more keywords
Pred-Skin: A Fast and Reliable Web Application to Assess Skin Sensitization Effect of Chemicals
Sign Up to like & getrecommendations! Published in 2017 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.7b00194
Abstract: Chemically induced skin sensitization is a complex immunological disease with a profound impact on quality of life and working ability. Despite some progress in developing alternative methods for assessing the skin sensitization potential of chemical… read more here.
Keywords: pred skin; skin sensitization; application; chemical ... See more keywords
Chemical Reactivity and Skin Sensitization Studies on a Series of Chloro- and Fluoropyrroles—A Computational Approach
Sign Up to like & getrecommendations! Published in 2021 at "ACS Omega"
DOI: 10.1021/acsomega.1c02436
Abstract: Global density functional descriptors analysis on a series of chloro- and fluoropyrroles provide vital data concerning their overall biochemical activities. In this study, a comprehensive investigation is presented for a series of chloro- and fluoropyrroles… read more here.
Keywords: chloro fluoropyrroles; series chloro; skin sensitization; reactivity ... See more keywords