Acyltransferase skinny hedgehog regulates TGFβ-dependent fibroblast activation in SSc
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DOI: 10.1136/annrheumdis-2019-215066
Abstract: Objectives Systemic sclerosis (SSc) is characterised by aberrant hedgehog signalling in fibrotic tissues. The hedgehog acyltransferase (HHAT) skinny hedgehog catalyses the attachment of palmitate onto sonic hedgehog (SHH). Palmitoylation of SHH is required for multimerisation… read more here.
Keywords: ssc; tgf dependent; hedgehog; hedgehog signalling ... See more keywords