Skipping events impose repeated binding attempts: profound kinetic implications of protein–DNA conformational changes
Sign Up to like & getrecommendations! Published in 2024 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkae333
Abstract: Abstract The kinetics of protein–DNA recognition, along with its thermodynamic properties, including affinity and specificity, play a central role in shaping biological function. Protein–DNA recognition kinetics are characterized by two key elements: the time taken… read more here.
Keywords: dna; dna recognition; skipping events; protein dna ... See more keywords
Abstract 1764: Accurate and reproducible detection of fusions and exon skipping events in NSCLC-derived samples using a comprehensive, targeted RNA-Seq system across multiple laboratories
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DOI: 10.1158/1538-7445.am2017-1764
Abstract: • Targeted RNA-Seq of expression markers in NSCLC FFPE tumors requires integrated reagents, protocols, and interpretive software that can ensure consistent results across laboratories. • In this study, a comprehensive targeted NGS system, the QuantideX®… read more here.
Keywords: skipping events; system; targeted rna; comprehensive targeted ... See more keywords
Identification of exon skipping events associated with Alzheimer’s disease in the human hippocampus
Sign Up to like & getrecommendations! Published in 2018 at "BMC Medical Genomics"
DOI: 10.1186/s12920-018-0453-8
Abstract: BackgroundAt least 90% of human genes are alternatively spliced. Alternative splicing has an important function regulating gene expression and miss-splicing can contribute to risk for human diseases, including Alzheimer’s disease (AD).MethodsWe developed a splicing decision… read more here.
Keywords: human hippocampus; skipping events; alzheimer disease; exon skipping ... See more keywords