Unraveling Small Molecule-Mediated Sirtuin 3 Activation at a Distinct Binding Site for Cardioprotective Therapies
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DOI: 10.1021/acscentsci.5c00023
Abstract: Sirtuin 3 (SIRT3), a pivotal mitochondrial deacetylase, plays a critical role in restoring mitochondrial function, particularly through the activation of autophagy. Despite its promise as a cardioprotective target, developing SIRT3 activators and their therapeutic applications… read more here.
Keywords: sklb 11a; sirt3; distinct binding; activation ... See more keywords