Novel selective TOPK inhibitor SKLB-C05 inhibits colorectal carcinoma growth and metastasis.
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DOI: 10.1016/j.canlet.2018.12.016
Abstract: The mitogen-activated protein kinase (MAPK) signaling pathway member T-LAK cell-originated protein kinase/PDZ-binding kinase (TOPK/PBK) is closely involved in tumorigenesis and progression. Its overexpression in colorectal carcinoma (CRC) exacerbates tumor malignancy, promotes metastasis and results in… read more here.
Keywords: topk; sklb c05; kinase; crc ... See more keywords