Role of Klotho and AGE/RAGE-Wnt/β-Catenin Signalling Pathway on the Development of Cardiac and Renal Fibrosis in Diabetes
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DOI: 10.3390/ijms24065241
Abstract: Fibrosis plays an important role in the pathogenesis of long-term diabetic complications and contributes to the development of cardiac and renal dysfunction. The aim of this experimental study, performed in a long-term rat model, which… read more here.
Keywords: role; wnt catenin; development cardiac; rage ... See more keywords
Effect of Dietary Phosphorous Restriction on Fibroblast Growth 2 Factor-23 and sKlotho Levels in Patients with Stages 1–2 Chronic Kidney Disease
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DOI: 10.3390/nu14163302
Abstract: Hyperphosphatemia has emerged as an independent risk factor for cardiovascular disease (CVD) and excess mortality in chronic kidney disease (CKD). The study evaluates the effect of dietary phosphorus (Ph) restriction (DPhR) at an early stage… read more here.
Keywords: restriction; disease; chronic kidney; sklotho ... See more keywords
Serum and Urinary Soluble α-Klotho as Markers of Kidney and Vascular Impairment
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DOI: 10.3390/nu15061470
Abstract: This study was designed to investigate the controversy on the potential role of sKlotho as an early biomarker in Chronic Kidney Disease–Mineral Bone Disorder (CKD-MBD), to assess whether sKlotho is a reliable marker of kidney… read more here.
Keywords: serum; kidney; klotho; osteogenic differentiation ... See more keywords