A novel all‐trans retinoic acid derivative inhibits proliferation and induces apoptosis of myelodysplastic syndromes cell line SKM‐1 cells via up‐regulating p53
Sign Up to like & getrecommendations! Published in 2018 at "International Immunopharmacology"
DOI: 10.1016/j.intimp.2018.10.041
Abstract: &NA; Myelodysplastic syndromes (MDS) are a varied set of hematologic neoplasms and a high risk of progression to acute myeloid leukemia (AML). 4‐Amino‐2‐trifluoromethyl‐phenyl retinate (ATPR), a novel all‐trans retinoic acid (ATRA) derivative, play an important… read more here.
Keywords: trans retinoic; myelodysplastic syndromes; skm cells; novel trans ... See more keywords
Phosphodiesterases S-sulfhydration contributes to human skeletal muscle function.
Sign Up to like & getrecommendations! Published in 2022 at "Pharmacological research"
DOI: 10.1016/j.phrs.2022.106108
Abstract: The increase in intracellular calcium is influenced by cyclic nucleotides (cAMP and cGMP) content, which rating is governed by phosphodiesterases (PDEs) activity.Despite it has been demonstrated a beneficial effect of PDEs inhibitors in different pathological… read more here.
Keywords: camp cgmp; sulfhydration contributes; pdes activity; contractility ... See more keywords
Resveratrol Suppresses Growth and Migration of Myelodysplastic Cells by Inhibiting the Expression of Elevated Cyclin D1 (CCND1).
Sign Up to like & getrecommendations! Published in 2017 at "DNA and cell biology"
DOI: 10.1089/dna.2017.3846
Abstract: Myelodysplastic syndromes (MDS) are a group of heterogeneous diseases characterized by poorly formed blood cells. We wanted to elucidate the underlying molecular mechanism to better determine pathogenesis, prognosis, diagnosis, and treatment for patients with MDS.… read more here.
Keywords: resveratrol; migration; expression; ccnd1 ... See more keywords
Metabolic effects of skeletal muscle-specific deletion of beta-arrestin-1 and -2 in mice
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DOI: 10.1371/journal.pgen.1008424
Abstract: Type 2 diabetes (T2D) has become a major health problem worldwide. Skeletal muscle (SKM) is the key tissue for whole-body glucose disposal and utilization. New drugs aimed at improving insulin sensitivity of SKM would greatly… read more here.
Keywords: skeletal muscle; barr2; barr1 barr2; mice ... See more keywords
Empagliflozin Preserves Skeletal Muscle Function in a HFpEF Rat Model
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231910989
Abstract: Besides structural alterations in the myocardium, heart failure with preserved ejection fraction (HFpEF) is also associated with molecular and physiological alterations of the peripheral skeletal muscles (SKM) contributing to exercise intolerance often seen in HFpEF… read more here.
Keywords: function; skm; mitochondrial function; hfpef ... See more keywords