Peptides from sesame cake reduce oxidative stress and amyloid-β-induced toxicity by upregulation of SKN-1 in a transgenic Caenorhabditis elegans model of Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Functional Foods"
DOI: 10.1016/j.jff.2017.10.032
Abstract: Abstract Alzheimer’s disease (AD) is a serious worldwide public health problem. Its pathogenesis is believed to be driven by amyloid-β (Aβ)-induced oxidative stress and toxicity. We investigated the effects of peptides from sesame cake (PSC),… read more here.
Keywords: skn; psc; induced toxicity; stress ... See more keywords
Arginine methylation of SKN-1 promotes oxidative stress resistance in Caenorhabditis elegans
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DOI: 10.1016/j.redox.2019.101111
Abstract: Caenorhabditis elegans NRF (NF-E2-related factor)/CNC (Cap'n'collar) transcription factor, Skinhead-1 (SKN-1), is conservatively critical for promoting phase II detoxification gene expressions in response to oxidative stress. SKN-1 activity is controlled by well-known phosphorylation and recently-reported O-GlcNAcylation.… read more here.
Keywords: skn; caenorhabditis elegans; arginine methylation; oxidative stress ... See more keywords
O-GlcNAcylation of SKN-1 modulates the lifespan and oxidative stress resistance in Caenorhabditis elegans
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DOI: 10.1038/srep43601
Abstract: In C. elegans, the transcription factor skinhead-1 (SKN-1), the ortholog of human NF-E2-related factor 2 (Nrf-2), plays important roles in oxidative stress defense and aging processes. It has been documented that the activity of SKN-1… read more here.
Keywords: skn; stress resistance; lifespan oxidative; oxidative stress ... See more keywords
MEKK-3 Acts Cooperatively with NSY-1 in SKN-1-Dependent Manner against Oxidative Stress and Aging in Caenorhabditis elegans
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DOI: 10.3390/biology11101526
Abstract: Simple Summary Oxidative stress has been linked to myriad pathologies and aging. Here, we show that MEKK-3- and NSY-1-mediated nuclear translocation of SKN-1 is critical for protection against oxidative stress and for longevity in Caenorhabditis… read more here.
Keywords: stress; mekk nsy; oxidative stress; skn ... See more keywords
2-Butoxytetrahydrofuran and Palmitic Acid from Holothuria scabra Enhance C. elegans Lifespan and Healthspan via DAF-16/FOXO and SKN-1/NRF2 Signaling Pathways
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DOI: 10.3390/ph15111374
Abstract: Extracts from a sea cucumber, Holothuria scabra, have been shown to exhibit various pharmacological properties including anti-oxidation, anti-aging, anti-cancer, and anti-neurodegeneration. Furthermore, certain purified compounds from H. scabra displayed neuroprotective effects against Parkinson’s and Alzheimer’s… read more here.
Keywords: holothuria scabra; skn; acid; palmitic acid ... See more keywords