Peptides from sesame cake reduce oxidative stress and amyloid-β-induced toxicity by upregulation of SKN-1 in a transgenic Caenorhabditis elegans model of Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Functional Foods"
DOI: 10.1016/j.jff.2017.10.032
Abstract: Abstract Alzheimer’s disease (AD) is a serious worldwide public health problem. Its pathogenesis is believed to be driven by amyloid-β (Aβ)-induced oxidative stress and toxicity. We investigated the effects of peptides from sesame cake (PSC),… read more here.
Keywords: skn; psc; induced toxicity; stress ... See more keywords
Arginine methylation of SKN-1 promotes oxidative stress resistance in Caenorhabditis elegans
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DOI: 10.1016/j.redox.2019.101111
Abstract: Caenorhabditis elegans NRF (NF-E2-related factor)/CNC (Cap'n'collar) transcription factor, Skinhead-1 (SKN-1), is conservatively critical for promoting phase II detoxification gene expressions in response to oxidative stress. SKN-1 activity is controlled by well-known phosphorylation and recently-reported O-GlcNAcylation.… read more here.
Keywords: skn; caenorhabditis elegans; arginine methylation; oxidative stress ... See more keywords
Serotonin deficiency from constitutive SKN-1 activation drives pathogen apathy
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DOI: 10.1038/s41467-024-52233-5
Abstract: When an organism encounters a pathogen, the host innate immune system activates to defend against pathogen colonization and toxic xenobiotics produced. C. elegans employ multiple defense systems to ensure survival when exposed to Pseudomonas aeruginosa… read more here.
Keywords: pathogen apathy; constitutive skn; activation; drives pathogen ... See more keywords
O-GlcNAcylation of SKN-1 modulates the lifespan and oxidative stress resistance in Caenorhabditis elegans
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DOI: 10.1038/srep43601
Abstract: In C. elegans, the transcription factor skinhead-1 (SKN-1), the ortholog of human NF-E2-related factor 2 (Nrf-2), plays important roles in oxidative stress defense and aging processes. It has been documented that the activity of SKN-1… read more here.
Keywords: skn; stress resistance; lifespan oxidative; oxidative stress ... See more keywords
Protein sequence editing defines distinct and overlapping functions of SKN-1A/Nrf1 and SKN-1C/Nrf2
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DOI: 10.1371/journal.pgen.1011780
Abstract: The Nrf/NFE2L family of transcription factors regulates redox balance, xenobiotic detoxification, metabolism, proteostasis, and aging. Nrf1/NFE2L1 is primarily responsible for stress-responsive upregulation of proteasome subunit genes and is essential for adaptation to proteotoxic stress. Nrf2/NFE2L2… read more here.
Keywords: sequence editing; skn nrf1; sequence; nrf1 skn ... See more keywords
MEKK-3 Acts Cooperatively with NSY-1 in SKN-1-Dependent Manner against Oxidative Stress and Aging in Caenorhabditis elegans
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DOI: 10.3390/biology11101526
Abstract: Simple Summary Oxidative stress has been linked to myriad pathologies and aging. Here, we show that MEKK-3- and NSY-1-mediated nuclear translocation of SKN-1 is critical for protection against oxidative stress and for longevity in Caenorhabditis… read more here.
Keywords: stress; mekk nsy; oxidative stress; skn ... See more keywords
2-Butoxytetrahydrofuran and Palmitic Acid from Holothuria scabra Enhance C. elegans Lifespan and Healthspan via DAF-16/FOXO and SKN-1/NRF2 Signaling Pathways
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceuticals"
DOI: 10.3390/ph15111374
Abstract: Extracts from a sea cucumber, Holothuria scabra, have been shown to exhibit various pharmacological properties including anti-oxidation, anti-aging, anti-cancer, and anti-neurodegeneration. Furthermore, certain purified compounds from H. scabra displayed neuroprotective effects against Parkinson’s and Alzheimer’s… read more here.
Keywords: holothuria scabra; skn; acid; palmitic acid ... See more keywords