The structural role of Skp1 in the synaptonemal complex is conserved in nematodes
Sign Up to like & getrecommendations! Published in 2024 at "Genetics"
DOI: 10.1093/genetics/iyae153
Abstract: Abstract The synaptonemal complex (SC) is a meiotic interface that assembles between parental chromosomes and is essential for gamete formation. While the dimensions and ultrastructure of the SC are conserved across eukaryotes, its protein components… read more here.
Keywords: structural role; role; skr; synaptonemal complex ... See more keywords
Skp1 isoforms are differentially modified by a dual function prolyl 4-hydroxylase/N-acetylglucosaminyltransferase in a plant pathogen.
Sign Up to like & getrecommendations! Published in 2019 at "Glycobiology"
DOI: 10.1093/glycob/cwz049
Abstract: Skp1 is hydroxylated by an O2-dependent prolyl hydroxylase (PhyA) that contributes to O2-sensing in the social amoeba Dictyostelium and the mammalian pathogen Toxoplasma gondii. HO-Skp1 is subject to glycosylation and the resulting pentasaccharide affects Skp1… read more here.
Keywords: pathogen; skp1 isoforms; plant pathogen; skp1 ... See more keywords
Abstract 519: A novel Skp1 inhibitor has potent preclinical efficacy against metastatic castration-resistant prostate cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-519
Abstract: Purpose: Despite numerous therapeutic modalities, including chemotherapy and next-generation androgen deprivation therapy, metastatic castration-resistant prostate cancer (mCRPC) remains a dreadful evolution and still bears a poor prognosis for most patients who develop metastases to bones… read more here.
Keywords: cell; prostate cancer; skp1; mcrpc ... See more keywords