Inhibition of Skp2 enhances doxorubicin‐induced cell death in B cell precursor acute lymphoblastic leukemia
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11779
Abstract: S‐phase kinase‐associated protein 2 (Skp2) is a well‐defined component of the Skp2‐Culin1‐F‐box (SCF) E3 ubiquitin ligase complex, which is involved in cell cycle progression and considered a prognostic marker in cancers. Overexpression of Skp2 is… read more here.
Keywords: inhibition skp2; cell; skp2; lymphoblastic leukemia ... See more keywords
Discovery of Novel 1,3-Diphenylpyrazine Derivatives as Potent S-Phase Kinase-Associated Protein 2 (Skp2) Inhibitors for the Treatment of Cancer.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01675
Abstract: F-box protein S-phase kinase-associated protein 2 (Skp2) is a component of cullin-RING ligases, which is responsible for recruiting and ubiquitinating substrates and subsequently plays its proteolytic and non-proteolytic role. High expression of Skp2 is frequently… read more here.
Keywords: skp2; phase kinase; protein skp2; protein ... See more keywords
Skp2 deficiency restricts the progression and stem cell features of castration-resistant prostate cancer by destabilizing Twist
Sign Up to like & getrecommendations! Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2017.64
Abstract: Castration-resistant prostate cancer (CRPC) remains a major clinical challenge because of the lack of effective targeted therapy for its treatment. The mechanism underlying how CRPC gains resistance toward hormone depletion and other forms of chemotherapy… read more here.
Keywords: prostate; skp2; progression; cancer ... See more keywords
Quinacrine upregulates p21/p27 independent of p53 through autophagy-mediated downregulation of p62-Skp2 axis in ovarian cancer
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-20531-w
Abstract: We have previously shown that the anti-malarial compound Quinacrine (QC) inhibits ovarian cancer (OC) growth by modulating autophagy. In the present study we extended these studies to identify the molecular pathways regulated by QC to… read more here.
Keywords: skp2; independent p53; p62; downregulation ... See more keywords
miR-1297 Promotes Cell Proliferation of Non-Small Cell Lung Cancer Cells: Involving in PTEN/Akt/Skp2 Signaling Pathway.
Sign Up to like & getrecommendations! Published in 2017 at "DNA and cell biology"
DOI: 10.1089/dna.2017.3886
Abstract: Phosphatase and tensin homolog deleted on chromosome ten (PTEN) is a lipid and protein phosphatase and possesses an antitumor effect in lung cancers. miRNAs are reportedly abnormally expressed in human lung cancers. However, whether miRNA… read more here.
Keywords: skp2; mir 1297; expression; cell ... See more keywords
FAK in the nucleus prevents VSMC proliferation by promoting p27 and p21 expression via Skp2 degradation.
Sign Up to like & getrecommendations! Published in 2021 at "Cardiovascular research"
DOI: 10.1093/cvr/cvab132
Abstract: AIM Vascular smooth muscle cells (VSMCs) normally exhibit a very low proliferative rate. Vessel injury triggers VSMC proliferation, in part, through focal adhesion kinase (FAK) activation, which increases transcription of cyclin D1, a key activator… read more here.
Keywords: degradation; skp2; fak; proliferation ... See more keywords
AhR activation promotes Treg cell generation by enhancing Lkb1-mediated fatty acid oxidation via the Skp2/K63-ubiquitination pathway.
Sign Up to like & getrecommendations! Published in 2023 at "Immunology"
DOI: 10.1111/imm.13638
Abstract: Several aryl hydrocarbon receptor (AhR) agonists have been reported to promote the generation of regulatory T cells (Treg cells), and the action mechanisms need to be identified. In this study, we addressed the underlying mechanism… read more here.
Keywords: skp2; k63 ubiquitination; generation; lkb1 ... See more keywords
Abstract 2125: Flavokawain A, a kava chalcone, inhibits growth and invasion of human osteosarcoma cells by targeting Skp2
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-2125
Abstract: Purpose: Osteosarcoma (OS) is the most common primary bone malignancy with a high propensity for local invasion and distant metastasis. Flavokawain A (FKA), a major chalcone from kava extract, has been reported to have antitumor… read more here.
Keywords: skp2; invasion; cell lines; inhibits growth ... See more keywords
Abstract 553: SKP2 knockout induces macrophage infiltration in p53/Rb1 null transgenic mouse models of osteosarcoma and drives gene expression correlated with improved survival in patients
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-553
Abstract: Background: Osteosarcoma (OS) is an aggressive cancer of the bone with a poor prognosis. OS often involve mutations of tumor suppressors RB1 and TP53. One putative proto-oncogene in OS is SKP2, which codes for a… read more here.
Keywords: infiltration; skp2; transgenic mouse; knockout ... See more keywords
SKP2 Contributes to AKT Activation by Ubiquitination Degradation of PHLPP1, Impedes Autophagy, and Facilitates the Survival of Thyroid Carcinoma.
Sign Up to like & getrecommendations! Published in 2023 at "Molecules and cells"
DOI: 10.14348/molcells.2022.2242
Abstract: Papillary thyroid carcinoma (PTC) is the most common subtype of thyroid carcinoma. Despite a good prognosis, approximately a quarter of PTC patients are likely to relapse. Previous reports suggest an association between S-phase kinase-associated protein… read more here.
Keywords: skp2; thyroid carcinoma; ptc; phlpp1 ... See more keywords
Small-molecule compounds inhibiting S-phase kinase-associated protein 2: A review
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2023.1122008
Abstract: S-phase kinase-associated protein 2 (Skp2) is a substrate-specific adaptor in Skp1-CUL1-ROC1-F-box E3 ubiquitin ligases and widely regarded as an oncogene. Therefore, Skp2 has remained as an active anticancer research topic since its discovery. Accordingly, the… read more here.
Keywords: skp2; kinase associated; associated protein; phase kinase ... See more keywords