Effect of Chiral Purity on Adjuvanticity of Archaeol-Based Glycolipids.
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DOI: 10.1021/acs.jmedchem.2c00072
Abstract: Archaeosomes composed of sulfated lactosyl archaeol (SLA) glycolipids from stereoisomerically pure archaeol (1) are vaccine adjuvants that can boost immunogenicity and vaccine efficacy in preclinical models. Herein, we report a new synthesis of 2,3-bis((3,7,11,15-tetramethylhexadecyl)oxy) propan-1-ol… read more here.
Keywords: effect; adjuvanticity; stereochemistry; effect chiral ... See more keywords