SLAM‐seq reveals early transcriptomic response mechanisms upon glutamine deprivation in Chinese hamster ovary cells
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28320
Abstract: Mammalian cells frequently encounter subtle perturbations during recombinant protein production. Identifying the genetic factors that govern the cellular stress response can facilitate targeted genetic engineering to obtain production cell lines that demonstrate a higher stress… read more here.
Keywords: chinese hamster; seq; hamster ovary; slam seq ... See more keywords
Transcriptome dynamics in mouse amygdala under acute and chronic stress revealed by thiol-labeled RNA sequencing
Sign Up to like & getrecommendations! Published in 2024 at "Neurobiology of Stress"
DOI: 10.1101/2024.01.12.573386
Abstract: Both acute and chronic stress have significant impact on brain functions. The amygdala is essential in mediating stress responses, but how its transcriptomic dynamics change under stress remains elusive. To overcome the difficulties in detecting… read more here.
Keywords: stress; slam seq; rna; seq ... See more keywords
Identification of Transcriptional Targets of NSD2 and the Underlying Regulatory Mechanism in t(4;14) Multiple Myeloma Cells Using the Slam-Seq and d-TAG Technologies
Sign Up to like & getrecommendations! Published in 2024 at "Blood"
DOI: 10.1182/blood-2024-205654
Abstract: INTRODUCTION: Approximately 15% of multiple myeloma cases are featured with a t(4;14) translocation that places immunoglobulin enhancers in the vicinity of NSD2, resulting in gain of its expression which otherwise is silent. The translocation-driven expression… read more here.
Keywords: multiple myeloma; slam seq; depletion; h3k36me2 ... See more keywords