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   Articles with "slamf7" as a keyword



Isoxazole-based molecules restore NK cell immune surveillance in hepatocarcinogenesis by targeting TM4SF5 and SLAMF7 linkage

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recommendations! Published in 2025 at "Signal Transduction and Targeted Therapy"

DOI: 10.1038/s41392-024-02106-6

Abstract: Dynamic communication between hepatocytes and the environment is critical in hepatocellular carcinoma (HCC) development. Clinical immunotherapy against HCC is currently unsatisfactory and needs more systemic considerations, including the identification of new biomarkers and immune checkpoints.… read more here.

Keywords: isoxazole; slamf7; tm4sf5; hcc ... See more keywords

Repolarization of immunosuppressive macrophages by targeting SLAMF7-regulated CCL2 signaling sensitizes hepatocellular carcinoma to immunotherapy.

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recommendations! Published in 2024 at "Cancer research"

DOI: 10.1158/0008-5472.can-23-3106

Abstract: Immune checkpoint inhibitors have limited efficacy in hepatocellular carcinoma (HCC). Macrophages are the most abundant immune cells in HCC, suggesting that a better understanding of the intrinsic processes by which tumor cells regulate macrophages could… read more here.

Keywords: slamf7; immunotherapy; ccl2 signaling; hcc ... See more keywords

SLAMF7-CAR T cells eliminate myeloma and confer selective fratricide of SLAMF7+ normal lymphocytes.

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recommendations! Published in 2017 at "Blood"

DOI: 10.1182/blood-2017-04-778423

Abstract: SLAMF7 is under intense investigation as a target for immunotherapy in multiple myeloma. In this study, we redirected the specificity of T cells to SLAMF7 through expression of a chimeric antigen receptor (CAR) derived from… read more here.

Keywords: slamf7; myeloma; slamf7 car; normal lymphocytes ... See more keywords

SLAMF7 in Primary Effusion Lymphoma, Target for Individualized Therapy?

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recommendations! Published in 2018 at "Blood"

DOI: 10.1182/blood-2018-99-110054

Abstract: Primary effusion lymphoma (PEL) is a rare, aggressive form of B-cell lymphoma. With a median survival time of around six months the prognosis for PEL patients is poor. Therefore, there is a medical need for… read more here.

Keywords: lymphoma; slamf7; cell lines; pel ... See more keywords

SLAMF7 and TREM1 Mediate Immunogenic Cell Death in Colorectal Cancer Cells: Focus on Microsatellite Stability

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recommendations! Published in 2021 at "AntiCancer Research"

DOI: 10.21873/anticanres.15355

Abstract: Background/Aim: The aim of this study was to identify the association between SLAMF7 and TREM1 and anti-PD-1 drugs, and to determine whether they are molecular targets or predictors of responses to immunotherapy through induction of… read more here.

Keywords: immunogenic cell; trem1; slamf7; cell death ... See more keywords

SLAMF7 Signaling Reprograms T Cells toward Exhaustion in the Tumor Microenvironment.

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recommendations! Published in 2020 at "Journal of immunology"

DOI: 10.4049/jimmunol.2000300

Abstract: T cell exhaustion represents one of the most pervasive strategies tumors employ to circumvent the immune system. Although repetitive, cognate TCR signaling is recognized as the primary driving force behind this phenomenon, and it remains… read more here.

Keywords: cell; slamf7; exhaustion tumor; exhaustion ... See more keywords