SLAMF7-CAR T cells eliminate myeloma and confer selective fratricide of SLAMF7+ normal lymphocytes.
Sign Up to like & getrecommendations! Published in 2017 at "Blood"
DOI: 10.1182/blood-2017-04-778423
Abstract: SLAMF7 is under intense investigation as a target for immunotherapy in multiple myeloma. In this study, we redirected the specificity of T cells to SLAMF7 through expression of a chimeric antigen receptor (CAR) derived from… read more here.
Keywords: slamf7; myeloma; slamf7 car; normal lymphocytes ... See more keywords
SLAMF7 in Primary Effusion Lymphoma, Target for Individualized Therapy?
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-110054
Abstract: Primary effusion lymphoma (PEL) is a rare, aggressive form of B-cell lymphoma. With a median survival time of around six months the prognosis for PEL patients is poor. Therefore, there is a medical need for… read more here.
Keywords: lymphoma; slamf7; cell lines; pel ... See more keywords
SLAMF7 and TREM1 Mediate Immunogenic Cell Death in Colorectal Cancer Cells: Focus on Microsatellite Stability
Sign Up to like & getrecommendations! Published in 2021 at "AntiCancer Research"
DOI: 10.21873/anticanres.15355
Abstract: Background/Aim: The aim of this study was to identify the association between SLAMF7 and TREM1 and anti-PD-1 drugs, and to determine whether they are molecular targets or predictors of responses to immunotherapy through induction of… read more here.
Keywords: immunogenic cell; trem1; slamf7; cell death ... See more keywords
SLAMF7 Signaling Reprograms T Cells toward Exhaustion in the Tumor Microenvironment.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of immunology"
DOI: 10.4049/jimmunol.2000300
Abstract: T cell exhaustion represents one of the most pervasive strategies tumors employ to circumvent the immune system. Although repetitive, cognate TCR signaling is recognized as the primary driving force behind this phenomenon, and it remains… read more here.
Keywords: cell; slamf7; exhaustion tumor; exhaustion ... See more keywords