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   Articles with "slc" as a keyword



The macrocycle inhibitor landscape of SLC‐transporter

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recommendations! Published in 2024 at "Molecular Informatics"

DOI: 10.1002/minf.202300287

Abstract: In the past years the interest in Solute Carrier Transporters (SLC) has increased due to their potential as drug targets. At the same time, macrocycles demonstrated promising activities as therapeutic agents. However, the overall macrocycle/SLC‐transporter… read more here.

Keywords: macrocycle; slc; inhibitor; slc transporter ... See more keywords

Cross-tissue coordination between SLC nucleoside transporters regulates reproduction in Caenorhabditis elegans

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recommendations! Published in 2025 at "PLOS Genetics"

DOI: 10.1371/journal.pgen.1011425

Abstract: Metabolism is fundamental to organism physiology and pathology. From the intricate network of metabolic reactions, diverse chemical molecules, collectively termed metabolites, are produced. In multicellular organisms, metabolite communication between different tissues is vital for maintaining… read more here.

Keywords: slc; physiology; cross tissue; caenorhabditis elegans ... See more keywords

Preload-based Starling-like control of rotary blood pumps: An in-vitro evaluation

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recommendations! Published in 2017 at "PLoS ONE"

DOI: 10.1371/journal.pone.0172393

Abstract: Due to a shortage of donor hearts, rotary left ventricular assist devices (LVADs) are used to provide mechanical circulatory support. To address the preload insensitivity of the constant speed controller (CSC) used in conventional LVADs,… read more here.

Keywords: preload based; preload; blood; based starling ... See more keywords

Discovery of a novel 4-pyridyl SLC-0111 analog targeting tumor-associated carbonic anhydrase isoform IX through tail-based design approach with potent anticancer activity

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recommendations! Published in 2025 at "Frontiers in Chemistry"

DOI: 10.3389/fchem.2025.1571646

Abstract: Introduction: Carbonic anhydrase IX (CA IX) is a tumor-associated enzyme involved in cancer progression and survival. Targeting CA IX with selective inhibitors like SLC-0111 has shown therapeutic potential. This study aimed to develop a novel… read more here.

Keywords: slc 0111; slc; carbonic anhydrase; anticancer ... See more keywords

Estimation of Annual Secondary Lung Cancer Deaths Using Various Adjuvant Breast Radiotherapy Techniques for Early-Stage Cancers

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recommendations! Published in 2021 at "Frontiers in Oncology"

DOI: 10.3389/fonc.2021.713328

Abstract: Purpose Secondary lung cancer (SLC) can offset the benefit of adjuvant breast radiotherapy (RT), and risks compound sharply after 25 to 30 years. We hypothesized that SLC risk is mainly an issue for early-stage breast… read more here.

Keywords: breast; early stage; cancer; stage ... See more keywords