Potentiating SLC transporter activity: Emerging drug discovery opportunities
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DOI: 10.1016/j.bcp.2017.02.010
Abstract: Graphical abstract Figure. No caption available. Abstract Maintaining the integrity of cellular membranes is critical to protecting metabolic activities and genetic information from the environment. Regulation of transport across membranes of essential chemicals, including water,… read more here.
Keywords: slc transporters; emerging drug; potentiating slc; slc transporter ... See more keywords
Exome Sequence Data of Eight SLC Transporters Reveal That SLC22A1 and SLC22A3 Variants Alter Metformin Pharmacokinetics and Glycemic Control
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DOI: 10.3390/ph17101385
Abstract: Background: Type 2 diabetes (T2D) is one of the leading causes of mortality and is a public health challenge worldwide. Metformin is the first-choice treatment for T2D; its pharmacokinetics (PK) is facilitated by members of… read more here.
Keywords: metformin pharmacokinetics; slc transporters; slc22a3; glycemic control ... See more keywords