Decreased vitamin C uptake mediated by SLC2A3 promotes leukaemia progression and impedes TET2 restoration
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DOI: 10.1038/s41416-020-0788-8
Abstract: Vitamin C suppresses leukaemogenesis by modulating Tet methylcytosine dioxygenase (TET) activity. However, its beneficial effect in the treatment of patients with acute myeloid leukaemia (AML) remains controversial. In this study, we aimed to identify a… read more here.
Keywords: aml; decreased vitamin; slc2a3 expression; cell ... See more keywords
Identification of SLC2A3 as a prognostic indicator correlated with the NF-κB/EMT axis and immune response in head and neck squamous cell carcinoma
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DOI: 10.1080/19336950.2023.2208928
Abstract: ABSTRACT SLC2A3 is an important member of the glucose transporter superfamily. It has been recently suggested that upregulation of SLC2A3 is associated with poor survival and acts as a prognostic marker in a variety of… read more here.
Keywords: emt axis; cell; slc2a3; expression ... See more keywords
Impact of Placental SLC2A3 Deficiency during the First-Half of Gestation
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DOI: 10.3390/ijms232012530
Abstract: In the ruminant placenta, glucose uptake and transfer are mediated by facilitative glucose transporters SLC2A1 (GLUT1) and SLC2A3 (GLUT3). SLC2A1 is located on the basolateral trophoblast membrane, whereas SLC2A3 is located solely on the maternal-facing,… read more here.
Keywords: half gestation; first half; slc2a3; placental slc2a3 ... See more keywords