SLC45A2: A Melanoma Antigen with High Tumor Selectivity and Reduced Potential for Autoimmune Toxicity
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Immunology Research"
DOI: 10.1158/2326-6066.cir-17-0051
Abstract: T cell–based immunotherapy against melanoma-associated antigens can result in on-target/off-tumor cytotoxicity. SLC45A2, a protein overexpressed in melanoma compared with normal melanocytes, was identified as a T-cell target that may be less prone to inducing autoimmune… read more here.
Keywords: melanoma; slc45a2; tumor selectivity; selectivity reduced ... See more keywords
Identification and Computational Analysis of Novel TYR and SLC45A2 Gene Mutations in Pakistani Families With Identical Non-syndromic Oculocutaneous Albinism
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DOI: 10.3389/fgene.2020.00749
Abstract: Non-syndromic oculocutaneous albinism (nsOCA) is an inherited disorder of melanin biosynthesis with autosomal recessive mode of inheritance, presenting either hypopigmented or depigmented skin, hair, and eyes. It is genetically heterogeneous with seven loci (OCA1–OCA7) reported… read more here.
Keywords: slc45a2; tyr slc45a2; oculocutaneous albinism; non syndromic ... See more keywords