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   Articles with "slc7a5" as a keyword



Leucine-Dependent SLC7A5-PGAM5 Interaction Promotes Advanced Atherosclerosis Through Hindering Mitochondrial Function of Macrophages.

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recommendations! Published in 2025 at "Advanced science"

DOI: 10.1002/advs.202518359

Abstract: The residual risks of advanced atherosclerosis remain substantial despite current preventive strategies and pharmacotherapy. Circulating branched-chain amino acids are biomarkers of cardiovascular disease risk. However, the mechanism of leucine in atherosclerosis progression remains unclear. Leucine… read more here.

Keywords: mitochondrial function; pgam5; function; atherosclerosis ... See more keywords

SRC2 controls CD4+ T cell activation via stimulating c-Myc-mediated upregulation of amino acid transporter Slc7a5.

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recommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2221352120

Abstract: T cell activation stimulates substantially increased protein synthesis activity to accumulate sufficient biomass for cell proliferation. The protein synthesis is fueled by the amino acids transported from the environment. Steroid nuclear receptor coactivator 2 (SRC2) is… read more here.

Keywords: cell; cd4 cell; cell activation; amino acid ... See more keywords

P170 SLC7A5 promotes the progression of Ulcerative Colitis by regulating amino acid transport and intestinal epithelial autophagy

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recommendations! Published in 2024 at "Journal of Crohn's and Colitis"

DOI: 10.1093/ecco-jcc/jjad212.0300

Abstract: IBD has become a common chronic intestinal disease in China. Considering the important role of amino acid metabolism in inflammatory diseases, inhibition amino acid metabolism of inflammatory sites may be effective in alleviating UC (ulcerative… read more here.

Keywords: acid transport; slc7a5; amino; autophagy ... See more keywords

Integrating bioinformatics and machine learning to identify biomarkers of branched chain amino acid related genes in osteoarthritis

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recommendations! Published in 2025 at "BMC Musculoskeletal Disorders"

DOI: 10.1186/s12891-025-08779-6

Abstract: Branched-chain amino acids (BCAA) metabolism is significantly associated with osteoarthritis (OA), but the specific mechanism of BCAA related genes (BCAA-RGs) in OA is still unclear. Therefore, this research intended to identify potential biomarkers and mechanisms… read more here.

Keywords: bcaa rgs; slc3a2 slc7a5; related genes; slc7a5 ... See more keywords

TP63 transcriptionally regulates SLC7A5 to suppress ferroptosis in head and neck squamous cell carcinoma

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recommendations! Published in 2024 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2024.1445472

Abstract: Background Most head and neck squamous cell carcinoma (HNSCC) patients are diagnosed at an advanced local stage. While immunotherapy has improved survival rates, only a minority of patients respond durably to targeted immunotherapies, posing substantial… read more here.

Keywords: tp63; head neck; slc7a5; ferroptosis ... See more keywords