Ikaros Degradation By CC-220 (Iberdomide) Correlates with Normalization of SLE CD4 T Cell Phenotype
Sign Up to like & getrecommendations! Published in 2024 at "Blood"
DOI: 10.1182/blood-2024-200209
Abstract: Introduction: CC-220 is a second-generation IMiD drug that degrades members of the IKZF family and is being explored for treating Systemic Lupus Erythematosus (SLE). SLE is driven by an abnormal immune response, and adaptive immune… read more here.
Keywords: treatment; sle cells; sle; cell ... See more keywords
Restoration of NK Cell Cytotoxic Function With Elotuzumab and Daratumumab Promotes Elimination of Circulating Plasma Cells in Patients With SLE
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.645478
Abstract: Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease characterized by multiple cellular and molecular dysfunctions of the innate and adaptive immunity. Cytotoxic function of NK cells is compromised in patients with SLE. Herein, we… read more here.
Keywords: sle cells; circulating plasma; plasma cells; function ... See more keywords