Early life stress (ELS) promotes B cell expansion and aortic pathology in a mouse model of systemic lupus erythematosus (SLE)
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5728900
Abstract: SLE is an autoimmune disease that primarily affects young women and is associated with high rates of cardiovascular disease (CVD). Exposure to ELS (adversity in childhood such as verbal and physical abuse and/or familial dysfunction)… read more here.
Keywords: sle; sle mice; msew sle; pathology ... See more keywords
Fecal microbiota transplantation attenuates hypertension in a female mouse model of systemic lupus erythematosus
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5733546
Abstract: Systemic lupus erythematosus (SLE) is a prototypic multisystem autoimmune disorder that disproportionately affects women. SLE is characterized by a breach of immunological self-tolerance and the expansion of autoreactive T and B lymphocytes, leading to the… read more here.
Keywords: sle; sle mice; control; physiology ... See more keywords
Systemic Administration of α7-Nicotinic Acetylcholine Receptor Ligands Does Not Improve Renal Injury or Behavior in Mice With Advanced Systemic Lupus Erythematosus
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2021.642960
Abstract: There is a critical need for safe treatment options to control inflammation in patients with systemic lupus erythematosus (SLE) since the inflammation contributes to morbidity and mortality in advanced disease. Endogenous neuroimmune mechanisms like the… read more here.
Keywords: systemic lupus; inflammation; sle mice; mice advanced ... See more keywords
Lipopolysaccharide Challenge Reveals Hypothalamic-Pituitary-Adrenal Axis Dysfunction in Murine Systemic Lupus Erythematosus
Sign Up to like & getrecommendations! Published in 2018 at "Brain Sciences"
DOI: 10.3390/brainsci8100184
Abstract: Crosstalk between the brain and innate immune system may be dysregulated in systemic lupus erythematosus (SLE), a chronic autoimmune disease that presents with dysautonomia and aberrant inflammation. The hypothalamic-pituitary-adrenal (HPA) axis is an endogenous neuro-endocrine-immune… read more here.
Keywords: challenge; systemic lupus; hypothalamic pituitary; lupus erythematosus ... See more keywords