Targeting SleC and CspB in the Inhibition of Spore Germination in Clostridioides difficile.
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DOI: 10.1021/acs.jmedchem.4c03090
Abstract: Clostridioides difficile, a Gram-positive, spore-forming anaerobic bacterium, is a major healthcare threat. Its spores colonize the gut following dysbiosis caused by broad-spectrum antibiotics, remaining dormant until host's bile acid triggers germination into vegetative cells that… read more here.
Keywords: germination; slec cspb; spore germination; clostridioides difficile ... See more keywords