Sleep drive, not total sleep amount, increases seizure risk
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DOI: 10.1038/s41467-025-62311-x
Abstract: Sleep loss has been associated with increased seizure risk since antiquity. Using automated video detection of spontaneous seizures in Drosophila epilepsy models, we show that seizures worsen only when sleep restriction raises homeostatic “sleep drive,”… read more here.
Keywords: sleep amount; seizure risk; seizure; sleep drive ... See more keywords
PP2Acα regulates sleep amount and sleep homeostasis in mice
Sign Up to like & getrecommendations! Published in 2025 at "Communications Biology"
DOI: 10.1038/s42003-025-08437-6
Abstract: Genetic studies in mice have identified multiple sleep-regulating protein kinases, but the sleep functions of protein phosphatases remain largely unclear. Here, we performed adeno-associated virus-mediated somatic genetics analysis of PP2A catalytic subunits–PP2Acα and PP2Acβ–in sleep… read more here.
Keywords: mice; sleep amount; pp2ac; amount sleep ... See more keywords