Integrated stress response activation by sleep fragmentation during late gestation in mice leads to emergence of adverse metabolic phenotype in offspring.
Sign Up to like & getrecommendations! Published in 2017 at "Metabolism: clinical and experimental"
DOI: 10.1016/j.metabol.2017.01.026
Abstract: BACKGROUND Late gestational sleep fragmentation (SF) is highly prevalent particularly in obese women, and induces metabolic dysfunction in adult offspring mice. SF induces activation of the integrated stress response (ISR), which might be involved in… read more here.
Keywords: gestation; sleep fragmentation; integrated stress; mice ... See more keywords
0190 Impact of Menopause-Related Sleep Fragmentation on Daytime Sleepiness and Neurobehavioral Performance: Results of an Experimental Model
Sign Up to like & getrecommendations! Published in 2020 at "Sleep"
DOI: 10.1093/sleep/zsaa056.188
Abstract: Cognitive performance may be adversely affected during the menopause transition from hot flash-induced sleep fragmentation even without changes in sleep duration. We examined the effects of experimentally-induced sleep fragmentation without shortened sleep duration on daytime… read more here.
Keywords: state; sleep fragmentation; neurobehavioral performance; fragmentation ... See more keywords
Solriamfetol improves chronic sleep fragmentation-induced increases in sleep propensity and ameliorates explicit memory in male mice.
Sign Up to like & getrecommendations! Published in 2023 at "Sleep"
DOI: 10.1093/sleep/zsad057
Abstract: Obstructive sleep apnea (OSA) is a highly prevalent condition characterized by episodes of partial or complete breath cessation during sleep that induce sleep fragmentation (SF). One of the frequent manifestations of OSA is the presence… read more here.
Keywords: sleep fragmentation; sleep propensity; sol mod; mice ... See more keywords
Differential effect of intermittent hypoxia and sleep fragmentation on PD-1/PD-L1 upregulation.
Sign Up to like & getrecommendations! Published in 2019 at "Sleep"
DOI: 10.1093/sleep/zsz285
Abstract: Immunosurveillance is compromised in obstructive sleep apnea (OSA) patients as reflected by overexpression of the programmed death cell receptor and its ligand (PD-1/PD-L1) co-inhibitory axis. However, the contributions of intermittent hypoxia (IH) and sleep fragmentation… read more here.
Keywords: sleep fragmentation; hypoxia sleep; expression; upregulation ... See more keywords
Hyperexcitable arousal circuits drive sleep instability during aging
Sign Up to like & getrecommendations! Published in 2022 at "Science"
DOI: 10.1126/science.abh3021
Abstract: Sleep quality declines with age; however, the underlying mechanisms remain elusive. We found that hyperexcitable hypocretin/orexin (Hcrt/OX) neurons drive sleep fragmentation during aging. In aged mice, Hcrt neurons exhibited more frequent neuronal activity epochs driving… read more here.
Keywords: kcnq2; sleep fragmentation; hcrt; hcrt neurons ... See more keywords
Sleep fragmentation increases blood pressure and is associated with alterations in the gut microbiome and fecal metabolome in rats
Sign Up to like & getrecommendations! Published in 2020 at "Physiological Genomics"
DOI: 10.1152/physiolgenomics.00039.2020
Abstract: The gut microbiota, via the production of metabolites entering the circulation, plays a role in blood pressure regulation. Blood pressure is also affected by the characteristics of sleep. To date, no studies have examined relationships… read more here.
Keywords: sleep fragmentation; blood pressure; mean arterial; fragmentation ... See more keywords
A modified mouse model of perioperative neurocognitive disorders exacerbated by sleep fragmentation
Sign Up to like & getrecommendations! Published in 2022 at "Experimental Animals"
DOI: 10.1538/expanim.22-0053
Abstract: Aging is one of the greatest risk factors for postoperative cognitive dysfunction (POCD), also known as perioperative neurocognitive disorder (PND). Animal models of PND are usually induced in mice over 18 months of age, which… read more here.
Keywords: sleep fragmentation; pnd model; perioperative neurocognitive; model ... See more keywords
Sleep deprivation, sleep fragmentation, and social jet lag increase temperature preference in Drosophila
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2023.1175478
Abstract: Despite the fact that sleep deprivation substantially affects the way animals regulate their body temperature, the specific mechanisms behind this phenomenon are not well understood. In both mammals and flies, neural circuits regulating sleep and… read more here.
Keywords: temperature; sleep fragmentation; sleep deprivation; temperature preference ... See more keywords
Impact of Sleep Fragmentation on Cognition and Fatigue
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Environmental Research and Public Health"
DOI: 10.3390/ijerph192315485
Abstract: Sleep continuity and efficacy are essential for optimal cognitive functions. How sleep fragmentation (SF) impairs cognitive functioning, and especially cognitive fatigue (CF), remains elusive. We investigated the impact of induced SF on CF through the… read more here.
Keywords: impact; impact sleep; fatigue; sleep fragmentation ... See more keywords
Sleep Fragmentation Accelerates Carcinogenesis in a Chemical-Induced Colon Cancer Model
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24054547
Abstract: Aims of this study were to test whether sleep fragmentation (SF) increased carcinogenesis and to investigate the possible mechanisms of carcinogenesis in a chemical-induced colon cancer model. In this study, eight-week-old C57BL/6 mice were divided… read more here.
Keywords: group; colon cancer; sleep fragmentation; cancer ... See more keywords
Actigraphy-Derived Sleep Is Associated with Eating Behavior Characteristics
Sign Up to like & getrecommendations! Published in 2021 at "Nutrients"
DOI: 10.3390/nu13030852
Abstract: Poor sleep is a determinant of obesity, with overconsumption of energy contributing to this relationship. Eating behavior characteristics are predictive of energy intake and weight change and may underlie observed associations of sleep with weight… read more here.
Keywords: sleep fragmentation; behavior characteristics; tendency towards; sleep ... See more keywords