Integrative Proteome and Ubiquitinome Analyses Reveal the Substrates of BTBD9 and Its Underlying Mechanism in Sleep Regulation
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.1c07262
Abstract: Ubiquitination is a major posttranslational modification of proteins that affects their stability, and E3 ligases play a key role in ubiquitination by specifically recognizing their substrates. BTBD9, an adaptor of the Cullin-RING ligase complex, is… read more here.
Keywords: sleep regulation; btbd9 mediated; ubiquitination; substrates btbd9 ... See more keywords
Association between circadian sleep regulation and cortical gyrification in young and older adults.
Sign Up to like & getrecommendations! Published in 2023 at "Sleep"
DOI: 10.1093/sleep/zsad094
Abstract: The circadian system orchestrates sleep timing and structure and is altered with increasing age. Sleep propensity, and particularly REM sleep is under strong circadian control and has been suggested to play an important role in… read more here.
Keywords: older adults; rem sleep; cortical gyrification; sleep regulation ... See more keywords
The two‐process model of sleep regulation: Beginnings and outlook
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DOI: 10.1111/jsr.13598
Abstract: The two‐process model serves as a major conceptual framework in sleep science. Although dating back more than four decades, it has not lost its relevance for research today. Retracing its origins, I describe how animal… read more here.
Keywords: two process; model sleep; process model; process ... See more keywords
Conserved properties of Drosophila Insomniac link sleep regulation and synaptic function
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DOI: 10.1371/journal.pgen.1006815
Abstract: Sleep is an ancient animal behavior that is regulated similarly in species ranging from flies to humans. Various genes that regulate sleep have been identified in invertebrates, but whether the functions of these genes are… read more here.
Keywords: drosophila insomniac; synaptic function; inc; cul3 ... See more keywords
Integrative Role of 14-3-3ε in Sleep Regulation
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22189748
Abstract: Sleep is a crucial factor for health and survival in all animals. In this study, we found by proteomic analysis that some cancer related proteins were impacted by the circadian clock. The 14-3-3ε protein, expression… read more here.
Keywords: role sleep; integrative role; factor; sleep regulation ... See more keywords