Motivational and Valence‐Related Modulation of Sleep/Wake Behavior are Mediated by Midbrain Dopamine and Uncoupled from the Homeostatic and Circadian Processes
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202200640
Abstract: Motivation and its hedonic valence are powerful modulators of sleep/wake behavior, yet its underlying mechanism is still poorly understood. Given the well‐established role of midbrain dopamine (mDA) neurons in encoding motivation and emotional valence, here,… read more here.
Keywords: sleep wake; modulation; modulation sleep; motivational valence ... See more keywords
Clinical and Experimental Human Sleep-Wake Pharmacogenetics.
Sign Up to like & getrecommendations! Published in 2018 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2018_175
Abstract: Sleep and wakefulness are highly complex processes that are elegantly orchestrated by fine-tuned neurochemical changes among neuronal and non-neuronal ensembles, nuclei, and networks of the brain. Important neurotransmitters and neuromodulators regulating the circadian and homeostatic… read more here.
Keywords: sleep wake; human sleep; wake disorders; wake pharmacogenetics ... See more keywords
Pharmacosynthetic Deconstruction of Sleep-Wake Circuits in the Brain.
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DOI: 10.1007/164_2018_183
Abstract: Over the past decade, basic sleep research investigating the circuitry controlling sleep and wakefulness has been boosted by pharmacosynthetic approaches, including chemogenetic techniques using designed receptors exclusively activated by designer drugs (DREADD). DREADD offers a… read more here.
Keywords: sleep wake; pharmacosynthetic deconstruction; wake circuits; deconstruction sleep ... See more keywords
Sleep Physiology, Circadian Rhythms, Waking Performance and the Development of Sleep-Wake Therapeutics.
Sign Up to like & getrecommendations! Published in 2019 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2019_243
Abstract: Disturbances of the sleep-wake cycle are highly prevalent and diverse. The aetiology of some sleep disorders, such as circadian rhythm sleep-wake disorders, is understood at the conceptual level of the circadian and homeostatic regulation of… read more here.
Keywords: sleep wake; physiology; waking performance;
Neural Circuits for Sleep-Wake Regulation.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-15-7086-5_8
Abstract: The neural mechanisms of sleep, a fundamental biological behavior from invertebrates to humans, have been a long-standing mystery and present an enormous challenge. Gradually, perspectives on the neurobiology of sleep have been more various with… read more here.
Keywords: sleep wake; circuits sleep; rem sleep; cholinergic system ... See more keywords
Nigrostriatal and mesolimbic control of sleep–wake behavior in rat
Sign Up to like & getrecommendations! Published in 2019 at "Brain Structure and Function"
DOI: 10.1007/s00429-019-01921-w
Abstract: The midbrain dopamine system via the dorsal and ventral striatum regulates a wide range of behaviors. To dissect the role of dopaminergic projections to the dorsal striatum (nigrostriatal projection) and ventral striatum (mesolimbic projection) in… read more here.
Keywords: sleep wake; wake behavior; ventral striatum; nigrostriatal mesolimbic ... See more keywords
Examining the Behavioural Sleep-Wake Rhythm in Adults with Autism Spectrum Disorder and No Comorbid Intellectual Disability
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Autism and Developmental Disorders"
DOI: 10.1007/s10803-017-3042-3
Abstract: This study aimed to examine the behavioural sleep-wake rhythm in 36 adults with autism spectrum disorder (ASD) and to determine the prevalence of circadian sleep-wake rhythm disorders compared to age- and sex-matched controls. Participants completed… read more here.
Keywords: sleep wake; autism; disorder; wake rhythm ... See more keywords
The role of dopamine in mood disorders and the associated changes in circadian rhythms and sleep-wake cycle
Sign Up to like & getrecommendations! Published in 2019 at "Brain Research"
DOI: 10.1016/j.brainres.2018.11.031
Abstract: Dopamine is primarily produced in the substantia nigra (SN) and the ventral tegmentum area (VTA) in the brain. It plays a well-established role in the motor control, reward, mood regulation and addiction behaviour. Dopamine release… read more here.
Keywords: sleep wake; dopamine; mood; role ... See more keywords
Structural synaptic plasticity across sleep and wake
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DOI: 10.1016/j.cophys.2019.12.007
Abstract: Sleep-dependent synaptic plasticity is crucial for optimal cognition. However, establishing the direction of synaptic plasticity during sleep has been particularly challenging since data in support of both synaptic potentiation and depotentiation have been reported. This… read more here.
Keywords: plasticity across; sleep wake; across sleep; synaptic plasticity ... See more keywords
Short communication: Self-reported sleep-wake disturbances preceding onset of full-threshold mood and/or psychotic syndromes in community residing adolescents and young adults.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of affective disorders"
DOI: 10.1016/j.jad.2020.08.083
Abstract: BACKGROUND Insomnia may predict onset of mental disorders in adults. However, it is unclear whether the same directional relationship exists during the peak age range for the onset of major mental disorders and/or whether other… read more here.
Keywords: sleep wake; hypersomnia; insomnia; community residing ... See more keywords
Sleep-wake profiles and circadian rhythms of core temperature and melatonin in young people with affective disorders.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of psychiatric research"
DOI: 10.1016/j.jpsychires.2017.07.007
Abstract: While disturbances of the sleep-wake cycle are common in people with affective disorders, the characteristics of these disturbances differ greatly between individuals. This heterogeneity is likely to reflect multiple underlying pathophysiologies, with different perturbations in… read more here.
Keywords: sleep wake; people affective; circadian rhythms; affective disorders ... See more keywords