Liver-Specific Delivery of Sleeping Beauty Transposon System by Hydrodynamic Injection for Cancer Gene Validation.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8967-6_15
Abstract: Understanding the complex genetic background of cancers is key in developing effective targeted therapies. The Sleeping Beauty (SB) transposon system is a powerful and unbiased genetic editing tool that can be used for rapid screening… read more here.
Keywords: cancer; beauty transposon; sleeping beauty; transposon system ... See more keywords
Patent sleeping beauties: evolutionary trajectories and identification methods
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DOI: 10.1007/s11192-019-03123-x
Abstract: Sleeping Beauties in Science have attracted a lot of attention in scientometrics and beyond. However, sleeping beauties also appear in patent. In this paper, we put forward the concept of patent sleeping beauties. Since the… read more here.
Keywords: patent awakening; sleeping beauties; sleeping beauty; patent sleeping ... See more keywords
Direct Inference, Reichenbach's Principle, and the Sleeping Beauty Problem
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DOI: 10.1017/epi.2019.41
Abstract: A group of philosophers led by the late John Pollock has applied a method of reasoning about probability, known as direct inference and governed by a constraint known as Reichenbach's principle, to argue in support… read more here.
Keywords: direct inference; reichenbach principle; sleeping beauty; beauty problem ... See more keywords
Prolonged Expression of Secreted Enzymes in Dogs After Liver-Directed Delivery of Sleeping Beauty Transposons: Implications for Non-Viral Gene Therapy of Systemic Disease.
Sign Up to like & getrecommendations! Published in 2017 at "Human gene therapy"
DOI: 10.1089/hum.2017.004
Abstract: The non-viral, integrating Sleeping Beauty (SB) transposon system is efficient in treating systemic monogenic disease in mice, including hemophilia A and B caused by deficiency of blood clotting factors and mucopolysaccharidosis types I and VII… read more here.
Keywords: non viral; gene therapy; sleeping beauty; disease ... See more keywords
Engineered Sleeping Beauty transposase redirects transposon integration away from genes
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac092
Abstract: Abstract The Sleeping Beauty (SB) transposon system is a popular tool for genome engineering, but random integration into the genome carries a certain genotoxic risk in therapeutic applications. Here we investigate the role of amino… read more here.
Keywords: transposon integration; integration; amino acids; transposase ... See more keywords
Sleeping beauty syndrome presenting with insomnia
Sign Up to like & getrecommendations! Published in 2018 at "BMJ Case Reports"
DOI: 10.1136/bcr-2018-225873
Abstract: A young man previously diagnosed with Kleine-Levin syndrome (KLS) presented with abnormal behaviour over the last 8 days. This included decreased sleeping hours and appetite, hypersexuality, aggressiveness and visual hallucinations. All blood tests and investigations… read more here.
Keywords: insomnia; sleeping beauty; beauty syndrome; syndrome presenting ... See more keywords
Integration of Oncogenes via Sleeping Beauty as a Mouse Model of HPV16+ Oral Tumors and Immunologic Control
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Immunology Research"
DOI: 10.1158/2326-6066.cir-16-0358
Abstract: A preclinical mouse model of spontaneous, HPV+ oral tumors was generated. Sleeping beauty transposase system-mediated oncogene transfection was assisted by electroporation. This model allowed for the evaluation of disease intervention efficacy and analysis of tumor… read more here.
Keywords: sleeping beauty; model; hpv16; mouse ... See more keywords
Awakening sleeping beauty: production of propionic acid in Escherichia coli through the sbm operon requires the activity of a methylmalonyl-CoA epimerase
Sign Up to like & getrecommendations! Published in 2017 at "Microbial Cell Factories"
DOI: 10.1186/s12934-017-0735-4
Abstract: BackgroundPropionic acid is used primarily as a food preservative with smaller applications as a chemical building block for the production of many products including fabrics, cosmetics, drugs, and plastics. Biological production using propionibacteria would be… read more here.
Keywords: production; sbm operon; sleeping beauty; acid ... See more keywords
The occurrence of ‘Sleeping Beauty’ publications in medical research: Their scientific impact and technological relevance
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DOI: 10.1371/journal.pone.0223373
Abstract: We investigate publications in medical research that have gone unnoticed for a number of years after being published and then suddenly become cited to a significant degree. Such publications are called Sleeping Beauties (SBs). This… read more here.
Keywords: sbs; sleeping beauty; publications medical; medical research ... See more keywords
Sleeping beauty generated CD19 CAR T-Cell therapy for advanced B-Cell hematological malignancies
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1032397
Abstract: Chimeric antigen receptor (CAR) T-cell therapy has emerged recently as a standard of care treatment for patients with relapsed or refractory acute lymphoblastic leukemia (ALL) and several subtypes of B-cell non-Hodgkin lymphoma (NHL). However, its… read more here.
Keywords: car; cell therapy; sleeping beauty; car cell ... See more keywords
Contemporary Transposon Tools: A Review and Guide through Mechanisms and Applications of Sleeping Beauty, piggyBac and Tol2 for Genome Engineering
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22105084
Abstract: Transposons are mobile genetic elements evolved to execute highly efficient integration of their genes into the genomes of their host cells. These natural DNA transfer vehicles have been harnessed as experimental tools for stably introducing… read more here.
Keywords: beauty piggybac; transposon; sleeping beauty; piggybac tol2 ... See more keywords