Retrospective analysis of Schlafen11 (SLFN11) to predict the outcomes to therapies affecting the DNA damage response.
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DOI: 10.1038/s41416-021-01560-1
Abstract: BACKGROUND The absence of the putative DNA/RNA helicase Schlafen11 (SLFN11) is thought to cause resistance to DNA-damaging agents (DDAs) and PARP inhibitors. METHODS We developed and validated a clinically applicable SLFN11 immunohistochemistry assay and retrospectively… read more here.
Keywords: schlafen11 slfn11; retrospective analysis; response; slfn11 ... See more keywords
Dynamic expression of Schlafen 11 (SLFN11) in circulating tumour cells as a liquid biomarker in small cell lung cancer.
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DOI: 10.1038/s41416-022-01811-9
Abstract: INTRODUCTION Small cell lung cancer (SCLC) is an aggressive malignancy with no established biomarkers. Schlafen 11(SLFN11), a DNA/RNA helicase that sensitises cancer cells to DNA-damaging agents, has emerged as a promising predictive biomarker for several… read more here.
Keywords: expression; circulating tumour; biomarker; tumour cells ... See more keywords
Prognostic Impact of Schlafen 11 in Bladder Cancer Patients Treated with Platinum-based Chemotherapy.
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DOI: 10.1111/cas.15207
Abstract: The utility of Schlafen 11 (SLFN11) expression as a predictive biomarker for platinum-based chemotherapy has been established for cancers from different histologies. However, the therapeutic relevance of SLFN11 in bladder cancer (BC) is unknown. Here,… read more here.
Keywords: based chemotherapy; slfn11 expression; platinum based; slfn11 ... See more keywords
SLFN11 captures cancer-immunity interactions associated with platinum sensitivity in high-grade serous ovarian cancer
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DOI: 10.1172/jci.insight.146098
Abstract: Large independent analyses on cancer cell lines followed by functional studies have identified Schlafen 11 (SLFN11), a putative helicase, as the strongest predictor of sensitivity to DNA-damaging agents (DDAs), including platinum. However, its role as… read more here.
Keywords: platinum; grade serous; high grade; slfn11 ... See more keywords
SLFN11 biomarker status predicts response to lurbinectedin as a single agent and in combination with ATR inhibition in small cell lung cancer.
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DOI: 10.21037/tlcr-21-437
Abstract: Background Lurbinectedin recently received FDA accelerated approval as a second line treatment option for metastatic small cell lung cancer (SCLC). However, there are currently no established biomarkers to predict SCLC sensitivity or resistance to lurbinectedin… read more here.
Keywords: biomarker; slfn11; cell; lung cancer ... See more keywords
Schlafen family member 11 indicates favorable prognosis of patients with head and neck cancer following platinum-based chemoradiotherapy
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DOI: 10.3389/fonc.2022.978875
Abstract: Recently, Schlafen family member 11 (SLFN11) has been reported to increase the sensitivity of cancer cells to DNA-damaging agents, including platinum derivatives; thus, SLFN11 may be a predictive biomarker for platinum-based chemoradiotherapy (CRT). In this… read more here.
Keywords: slfn11; slfn11 expression; schlafen family; platinum based ... See more keywords
SLFN11 inhibits hepatocellular carcinoma tumorigenesis and metastasis by targeting RPS4X via mTOR pathway
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DOI: 10.7150/thno.42869
Abstract: Hepatocellular carcinoma (HCC) remains one of the most refractory malignancies worldwide. Schlafen family member 11 (SLFN11) has been reported to play an important role in inhibiting the production of human immunodeficiency virus 1 (HIV-1). However,… read more here.
Keywords: metastasis; mtor pathway; hcc; slfn11 ... See more keywords