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   Articles with "slice cultures" as a keyword



Investigating demyelination, efficient remyelination and remyelination failure in organotypic cerebellar slice cultures: Workflow and practical tips.

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recommendations! Published in 2022 at "Methods in cell biology"

DOI: 10.1016/bs.mcb.2021.12.011

Abstract: Healthy myelin is essential for proper brain function. When the myelin sheath is damaged, fast saltatory impulse conduction is lost and neuronal axons become vulnerable to degeneration. Thus, regeneration of the myelin sheath by encouraging… read more here.

Keywords: slice cultures; organotypic cerebellar; remyelination; demyelination ... See more keywords

P12.50.A UNLOCKING 3D INSIGHTS: ENHANCED SURVIVAL AND IMAGING METHODS FOR HUMAN CORTICAL SLICE CULTURES

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recommendations! Published in 2025 at "Neuro-Oncology"

DOI: 10.1093/neuonc/noaf193.429

Abstract: Human cortical slice cultures represent valuable ex vivo models, yet achieving robust long-term survival and enabling effective 3D tissue analysis remain key challenges. This study aimed to establish improved protocols addressing viability, tissue processing, and… read more here.

Keywords: whole mount; slice cultures; cortical slice; analysis ... See more keywords

Human brain slice cultures: translational applications and ethical considerations

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recommendations! Published in 2025 at "Life Science Alliance"

DOI: 10.26508/lsa.202403160

Abstract: This review outlines the scientific utility and ethical imperatives of human brain slice cultures, calling for global ethical standards in ex vivo neuroscience research. Human organotypic brain slice cultures have emerged as a pivotal tool… read more here.

Keywords: brain; slice cultures; human brain; brain slice ... See more keywords

Replacement of Mouse Microglia With Human Induced Pluripotent Stem Cell (hiPSC)-Derived Microglia in Mouse Organotypic Slice Cultures

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recommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"

DOI: 10.3389/fncel.2022.918442

Abstract: Microglia, the major immune cells in the brain, are reported to differ in gene expression patterns among species. Therefore, it would be preferable in some cases to use human microglia rather than mouse microglia in… read more here.

Keywords: derived microglia; mouse; hipsc; slice cultures ... See more keywords

Nimodipine Exerts Time-Dependent Neuroprotective Effect after Excitotoxical Damage in Organotypic Slice Cultures

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recommendations! Published in 2022 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms23063331

Abstract: During injuries in the central nervous system, intrinsic protective processes become activated. However, cellular reactions, especially those of glia cells, are frequently unsatisfactory, and further exogenous protective mechanisms are necessary. Nimodipine, a lipophilic L-type calcium… read more here.

Keywords: time; effect; time dependent; damage ... See more keywords