Identification and Characterization of an Inside-Out Folding Intermediate of T4 Phage Sliding Clamp.
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical journal"
DOI: 10.1016/j.bpj.2017.08.043
Abstract: Protein folding process involves formation of transiently occurring intermediates that are difficult to isolate and characterize. It is both necessary and interesting to characterize the structural conformations adopted by these intermediates, also called molten globules… read more here.
Keywords: sliding clamp; phage; protein folding; gp45 ... See more keywords
Iterative Structure-Based Optimization of Short Peptides Targeting the Bacterial Sliding Clamp.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c00918
Abstract: The bacterial DNA sliding clamp (SC), or replication processivity factor, is a promising target for the development of novel antibiotics. We report a structure-activity relationship study of a new series of peptides interacting within the… read more here.
Keywords: sliding clamp; based optimization; optimization short; structure based ... See more keywords
Mechanism of opening a sliding clamp
Sign Up to like & getrecommendations! Published in 2017 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkx665
Abstract: Abstract Clamp loaders load ring-shaped sliding clamps onto DNA where the clamps serve as processivity factors for DNA polymerases. In the first stage of clamp loading, clamp loaders bind and stabilize clamps in an open… read more here.
Keywords: clamp loader; sliding clamp; mechanism; clamp loaders ... See more keywords
Searching for Low Probability Opening Events in a DNA Sliding Clamp
Sign Up to like & getrecommendations! Published in 2022 at "Life"
DOI: 10.3390/life12020261
Abstract: The β subunit of E. coli DNA polymererase III is a DNA sliding clamp associated with increasing the processivity of DNA synthesis. In its free form, it is a circular homodimer structure that can accomodate… read more here.
Keywords: dna; dna sliding; searching low; sliding clamp ... See more keywords
Cryo-EM structures reveal high-resolution mechanism of a DNA polymerase sliding clamp loader
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.74175
Abstract: Sliding clamps are ring-shaped protein complexes that are integral to the DNA replication machinery of all life. Sliding clamps are opened and installed onto DNA by clamp loader AAA+ ATPase complexes. However, how a clamp… read more here.
Keywords: rfc; clamp loader; sliding clamp; dna ... See more keywords
Multistep loading of a DNA sliding clamp onto DNA by replication factor C
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.78253
Abstract: The DNA sliding clamp proliferating cell nuclear antigen (PCNA) is an essential co-factor for many eukaryotic DNA metabolic enzymes. PCNA is loaded around DNA by the ATP-dependent clamp loader replication factor C (RFC), which acts… read more here.
Keywords: pcna; dna; replication; dna sliding ... See more keywords