Interaction of a Model Peptide on Gram Negative and Gram Positive Bacterial Sliding Clamps.
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DOI: 10.1021/acsinfecdis.9b00089
Abstract: Bacterial sliding clamps control the access of DNA polymerases to the replication fork and are appealing targets for antibacterial drug development. It is therefore essential to decipher the polymerase-clamp binding mode across various bacterial species.… read more here.
Keywords: gram positive; interaction model; gram; bacterial sliding ... See more keywords
Diffusion of ring-shaped proteins along DNA: case study of sliding clamps
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DOI: 10.1093/nar/gky436
Abstract: Abstract Several DNA-binding proteins, such as topoisomerases, helicases and sliding clamps, have a toroidal (i.e. ring) shape that topologically traps DNA, with this quality being essential to their function. Many DNA-binding proteins that function, for… read more here.
Keywords: diffusion; dna; sliding clamps; shaped proteins ... See more keywords
From Processivity to Genome Maintenance: The Many Roles of Sliding Clamps
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DOI: 10.3390/genes13112058
Abstract: Sliding clamps play a pivotal role in the process of replication by increasing the processivity of the replicative polymerase. They also serve as an interacting platform for a plethora of other proteins, which have an… read more here.
Keywords: maintenance many; processivity genome; genome maintenance; sliding clamps ... See more keywords