Mutations in KIRREL1, a slit diaphragm component, cause steroid-resistant nephrotic syndrome.
Sign Up to like & getrecommendations! Published in 2019 at "Kidney international"
DOI: 10.1016/j.kint.2019.06.016
Abstract: Steroid-resistant nephrotic syndrome is a frequent cause of chronic kidney disease almost inevitably progressing to end-stage renal disease. More than 58 monogenic causes of SRNS have been discovered and majority of known steroid-resistant nephrotic syndrome… read more here.
Keywords: slit diaphragm; resistant nephrotic; mutations kirrel1; nephrotic syndrome ... See more keywords
MAGI-2 orchestrates the localization of backbone proteins in the slit diaphragm of podocytes.
Sign Up to like & getrecommendations! Published in 2020 at "Kidney international"
DOI: 10.1016/j.kint.2020.09.027
Abstract: Podocytes are highly specialized cells within the glomerulus that are essential for ultrafiltration. The slit-diaphragm between the foot processes of podocytes functions as a final filtration barrier to prevent serum protein leakage into urine. The… read more here.
Keywords: localization backbone; backbone proteins; slit diaphragm;
Selective endocytosis controls slit diaphragm maintenance and dynamics in Drosophila nephrocytes
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.03.01.482547
Abstract: The kidneys generate about 180 liters of primary urine per day by filtration of plasma. An essential part of the filtration barrier is the slit diaphragm, a multiprotein complex containing nephrin as major component. Filter… read more here.
Keywords: diaphragm maintenance; slit diaphragm; selective endocytosis; endocytosis controls ... See more keywords
Nephrin-Binding Ephrin-B1 at the Slit Diaphragm Controls Podocyte Function through the JNK Pathway.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American Society of Nephrology : JASN"
DOI: 10.1681/asn.2017090993
Abstract: Background B-type ephrins are membrane-bound proteins that maintain tissue function in several organs. We previously reported that ephrin-B1 is localized at the slit diaphragm of glomerular podocytes. However, the function of ephrin-B1 at this location… read more here.
Keywords: ephrin; jnk; phosphorylation; slit diaphragm ... See more keywords
Structural Basis of Highly Specific Interaction between Nephrin and MAGI1 in Slit Diaphragm Assembly and Signaling.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American Society of Nephrology : JASN"
DOI: 10.1681/asn.2017121275
Abstract: BACKGROUND The slit diaphragm is a specialized adhesion junction between opposing podocytes, establishing the final filtration barrier that prevents passage of proteins from the capillary lumen into the urinary space. Nephrin, the key structural and… read more here.
Keywords: magi1; pbm; slit diaphragm; nephrin pbm ... See more keywords
Nephrin Signaling Results in Integrin β1 Activation.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American Society of Nephrology : JASN"
DOI: 10.1681/asn.2018040362
Abstract: BACKGROUND Patients with certain mutations in the gene encoding the slit diaphragm protein Nephrin fail to develop functional slit diaphragms and display severe proteinuria. Many adult-onset glomerulopathies also feature alterations in Nephrin expression and function.… read more here.
Keywords: activation; slit diaphragm; nephrin signaling; sns c3g ... See more keywords
Tyrosine Phosphorylation of CD2AP Affects Stability of the Slit Diaphragm Complex.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American Society of Nephrology : JASN"
DOI: 10.1681/asn.2018080860
Abstract: BACKGROUND CD2-associated protein (CD2AP), a slit diaphragm-associated scaffolding protein involved in survival and regulation of the cytoskeleton in podocytes, is considered a "stabilizer" of the slit diaphragm complex that connects the slit diaphragm protein nephrin… read more here.
Keywords: tyrosine phosphorylation; slit diaphragm; cd2ap;
Thrombospondin Type 1 Domain-Containing 7A Localizes to the Slit Diaphragm and Stabilizes Membrane Dynamics of Fully Differentiated Podocytes.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American Society of Nephrology : JASN"
DOI: 10.1681/asn.2018090941
Abstract: BACKGROUND About 3%-5% of adults with membranous nephropathy have autoantibodies directed against thrombospondin type 1 domain-containing 7A (THSD7A), a podocyte-expressed transmembrane protein. However, the temporal and spatial expression of THSD7A and its biologic function for… read more here.
Keywords: expression; thrombospondin type; slit diaphragm; slit ... See more keywords
VDR/Atg3 axis regulates slit diaphragm to tight junction transition via p62-mediated autophagy pathway in diabetic nephropathy.
Sign Up to like & getrecommendations! Published in 2021 at "Diabetes"
DOI: 10.2337/db21-0205
Abstract: Foot process effacement is an important feature of early diabetic nephropathy (DN) which is closely related to the development of albuminuria. Under certain nephrotic conditions, the integrity and function of the glomerular slit diaphragm (SD)… read more here.
Keywords: transition; slit diaphragm; autophagic flux; diabetic nephropathy ... See more keywords
Rap1 Activity Is Essential for Focal Adhesion and Slit Diaphragm Integrity
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.790365
Abstract: Glomerular podocytes build, with their intercellular junctions, part of the kidney filter. The podocyte cell adhesion protein, nephrin, is essential for developing and maintaining slit diaphragms as functional loss in humans results in heavy proteinuria.… read more here.
Keywords: slit; slit diaphragm; diaphragm integrity; rap1 activity ... See more keywords
Using Drosophila Nephrocytes to Understand the Formation and Maintenance of the Podocyte Slit Diaphragm
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.837828
Abstract: The podocyte slit diaphragm (SD) is an essential component of the glomerular filtration barrier and its disruption is a common cause of proteinuria and many types of kidney disease. Therefore, better understanding of the pathways… read more here.
Keywords: slit diaphragm; podocyte slit; biology; formation maintenance ... See more keywords