Slit2/Robo1 signaling inhibits small‐cell lung cancer by targeting β‐catenin signaling in tumor cells and macrophages
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13289
Abstract: Small‐cell lung cancer (SCLC) is an aggressive neuroendocrine subtype of lung cancer with poor patient prognosis. However, the mechanisms that regulate SCLC progression and metastasis remain undefined. Here, we show that the expression of the… read more here.
Keywords: lung cancer; slit2; tumor cells; robo1 ... See more keywords
Slit2/Robo1 signaling is involved in angiogenesis of glomerular endothelial cells exposed to a diabetic-like environment
Sign Up to like & getrecommendations! Published in 2017 at "Angiogenesis"
DOI: 10.1007/s10456-017-9592-3
Abstract: Abnormal angiogenesis plays a pathological role in diabetic nephropathy (DN), contributing to glomerular hypertrophy and microalbuminuria. Slit2/Robo1 signaling participates in angiogenesis in some pathological contexts, but whether it is involved in glomerular abnormal angiogenesis of… read more here.
Keywords: pi3k; angiogenesis; robo1 signaling; slit2 robo1 ... See more keywords
The expression of Slit2 and Robo1 increased during retinoic acid syndrome in acute promyelocytic leukemia and impacted differentiated cell migration
Sign Up to like & getrecommendations! Published in 2022 at "Translational Oncology"
DOI: 10.1016/j.tranon.2022.101370
Abstract: Highlights • The upregulation of Robo1 and Slit2 was first found in APL patients.• The positive correlation between Robo1/Slit2 and retinoic acid syndrome was first demonstrated.• It was demonstrated for the first time that Slit2… read more here.
Keywords: acid syndrome; robo1; slit2; differentiated cell ... See more keywords
Slit2 ameliorates renal inflammation and fibrosis after hypoxia‐and lipopolysaccharide‐induced epithelial cells injury in vitro
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Cell Research"
DOI: 10.1016/j.yexcr.2017.02.001
Abstract: ABSTRACT Hypoxic acute kidney injury (AKI) is often incompletely repaired and leads to chronic kidney disease (CKD), which is characterized by tubulointerstitial inflammation and fibrosis. The Slit2 family of secreted glycoproteins is expressed in the… read more here.
Keywords: epithelial cells; fibrosis; induced epithelial; cells injury ... See more keywords
Slit2 signaling contributes to cholestatic fibrosis in mice by activation of hepatic stellate cells.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2019.111626
Abstract: Liver Cholestasis is a widespread disease of broad etiologies and ultimately results in fibrosis, which is still lacking effective therapeutic strategies. Activation of hepatic stellate cells (HSCs) is the key event of liver fibrosis. Here,… read more here.
Keywords: fibrosis; stellate cells; activation hepatic; hepatic stellate ... See more keywords
Expression of the axon guidance factor Slit2 and its receptor Robo1 in patients with Hirschsprung disease
Sign Up to like & getrecommendations! Published in 2021 at "Medicine"
DOI: 10.1097/md.0000000000026981
Abstract: Abstract Hirschsprung disease (HD) is a common form of digestive tract malformation in children. However, the pathogenesis of HD is not very clear. This study aimed to investigate the expression of slit guidance ligand 2… read more here.
Keywords: expression; slit2; robo1 patients; hirschsprung disease ... See more keywords
Slit2/Robo1 promotes synaptogenesis and functional recovery of spinal cord injury
Sign Up to like & getrecommendations! Published in 2017 at "NeuroReport"
DOI: 10.1097/wnr.0000000000000715
Abstract: Neuronal network reconstruction is a pivotal determinant for functional recovery after spinal cord injury (SCI), the process of which includes synaptogenesis. Slit2 protein has been identified as a key regulator of axon regeneration and synapse… read more here.
Keywords: sci; robo1; injury; slit2 ... See more keywords
Slit guidance ligand 2 promotes the inflammatory response of periodontitis through activation of the NF-κB signaling pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of periodontal research"
DOI: 10.1111/jre.12987
Abstract: BACKGROUND AND OBJECTIVES Periodontitis is a chronic multifactorial inflammatory disease associated with dental plaque biofilms. Slit guidance ligand 2 (SLIT2) has been shown to guide neuronal migration, regulate the inflammatory response and cancer progression. However,… read more here.
Keywords: slit2; inflammatory response; guidance ligand; periodontitis ... See more keywords
SLIT2 Rare Sequencing Variants Identified in Idiopathic Hypogonadotropic Hypogonadism
Sign Up to like & getrecommendations! Published in 2022 at "Hormone Research in Paediatrics"
DOI: 10.1159/000525769
Abstract: Introduction: Idiopathic hypogonadotropic hypogonadism (IHH) is a rare reproductive disorder resulting from gonadotropin-releasing hormone (GnRH) deficiency. However, in only approximately half of patients with IHH is it possible to identify a likely molecular diagnosis. Mice… read more here.
Keywords: ihh; slit2; idiopathic hypogonadotropic; rare sequencing ... See more keywords
Missense mutation in SLIT2 associated with congenital myopia, anisometropia, connective tissue abnormalities, and obesity
Sign Up to like & getrecommendations! Published in 2018 at "Orphanet Journal of Rare Diseases"
DOI: 10.1186/s13023-018-0885-4
Abstract: BackgroundSLIT2 is a protein ligand for the Roundabout (ROBO) receptor and was found to play a major role in repulsive midline axon guidance in central nervous system development. Based on studies utilizing knockout models, it… read more here.
Keywords: slit2; connective tissue; myopia anisometropia; congenital myopia ... See more keywords
A Study On The Correlation Between Slit2/Robo1 Signaling Pathway Proteins And Polymyositis/Dermatomyositis.
Sign Up to like & getrecommendations! Published in 2020 at "Current molecular medicine"
DOI: 10.2174/1566524020666200326102837
Abstract: AIMS To investigate the role of Slit2 and Robo1 during the vascular disease of Polymyositis (PM) / dermatomyositis (DM). BACKGROUND PM and DM are non-suppurative inflammatory myopathies that mainly invade the skeletal muscles. OBJECTIVE This… read more here.
Keywords: polymyositis dermatomyositis; robo1 signaling; signaling pathway; slit2 robo1 ... See more keywords