Crosstalk between the activated Slit2–Robo1 pathway and TGF‐β1 signalling promotes cardiac fibrosis
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DOI: 10.1002/ehf2.13095
Abstract: Previous reports indicated that the Slit2–Robo signalling pathway is involved in embryonic heart development and fibrosis in other solid organs, but its function in adult cardiac fibrosis has not been investigated. Here, we investigate the… read more here.
Keywords: fibrosis; cardiac fibrosis; activated slit2; slit2 robo1 ... See more keywords
Slit2/Robo1 signaling is involved in angiogenesis of glomerular endothelial cells exposed to a diabetic-like environment
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DOI: 10.1007/s10456-017-9592-3
Abstract: Abnormal angiogenesis plays a pathological role in diabetic nephropathy (DN), contributing to glomerular hypertrophy and microalbuminuria. Slit2/Robo1 signaling participates in angiogenesis in some pathological contexts, but whether it is involved in glomerular abnormal angiogenesis of… read more here.
Keywords: pi3k; angiogenesis; robo1 signaling; slit2 robo1 ... See more keywords
Alterted SLIT2/ROBO1 signalling is linked to impaired placentation of missed and threatened miscarriage in early pregnancy
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DOI: 10.1111/his.13250
Abstract: Two‐thirds of early pregnancy failures present with reduced trophoblast invasion, and SLIT2/ROBO1 signalling is considered to play an important role in trophoblast function during pregnancy. We investigated SLIT2/ROBO1 signalling associated with missed and threatened miscarriage… read more here.
Keywords: early pregnancy; slit2 robo1; robo1 signalling; missed threatened ... See more keywords
A Study On The Correlation Between Slit2/Robo1 Signaling Pathway Proteins And Polymyositis/Dermatomyositis.
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DOI: 10.2174/1566524020666200326102837
Abstract: AIMS To investigate the role of Slit2 and Robo1 during the vascular disease of Polymyositis (PM) / dermatomyositis (DM). BACKGROUND PM and DM are non-suppurative inflammatory myopathies that mainly invade the skeletal muscles. OBJECTIVE This… read more here.
Keywords: polymyositis dermatomyositis; robo1 signaling; signaling pathway; slit2 robo1 ... See more keywords