The Interaction between DNMT1 and High‐Mannose CD133 Maintains the Slow‐Cycling State and Tumorigenic Potential of Glioma Stem Cell
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202202216
Abstract: The quiescent/slow‐cycling state preserves the self‐renewal capacity of cancer stem cells (CSCs) and leads to the therapy resistance of CSCs. The mechanisms maintaining CSCs quiescence remain largely unknown. Here, it is demonstrated that lower expression… read more here.
Keywords: interaction; cd133; slow cycling; cycling state ... See more keywords
Characterization of slow cycling corneal limbal epithelial cells identifies putative stem cell markers
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-04006-y
Abstract: In order to identify reliable markers of corneal epithelial stem cells, we employed an inducible transgenic “pulse-chase” murine model (K5Tta × TRE-H2BGFP) to localize, purify, and characterize slow cycling cells in the cornea. The retention of GFP… read more here.
Keywords: slow cycling; stem cell; cell markers; putative stem ... See more keywords
Slow cycling [Numbers Don't Lie]
Sign Up to like & getrecommendations! Published in 2017 at "IEEE Spectrum"
DOI: 10.1109/mspec.2017.7934224
Abstract: Some technical advances are delayed by either a failure of imagination or a concatenation of obstructive circumstances. I can think of no better example of both of these than the bicycle. . Two centuries ago,… read more here.
Keywords: slow cycling; numbers lie; cycling numbers;
Intratumoral Genetic and Functional Heterogeneity in Pediatric Glioblastoma.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer research"
DOI: 10.1158/0008-5472.can-18-3441
Abstract: Pediatric glioblastoma (pGBM) is a lethal cancer with no effective therapies. To understand the mechanisms of tumor evolution in this cancer, we performed whole-genome sequencing with linked reads on longitudinally resected pGBM samples. Our analyses… read more here.
Keywords: slow cycling; glioblastoma; pediatric glioblastoma; cancer ... See more keywords
Slow-Cycling Cancer Stem Cells Regulate Progression and Chemoresistance in Colon Cancer
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/0008-5472.can-20-0378
Abstract: These findings illustrate the importance of a slow-cycling CSC subpopulation in colon cancer development and chemoresistance, with potential implications for the identified slow-cycling CSC signatures and the TCF1–PROX1–CDKN1C pathway as therapeutic targets. Cancer chemoresistance is… read more here.
Keywords: slow cycling; colon cancer; csc; cancer ... See more keywords
Bcl-xL enforces a slow-cycling state necessary for survival in the nutrient-deprived microenvironment of pancreatic cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer research"
DOI: 10.1158/0008-5472.can-22-0431
Abstract: Solid tumors possess heterogeneous metabolic microenvironments where oxygen and nutrient availability are plentiful ('fertile regions') or scarce ('arid regions'). While cancer cells residing in fertile regions proliferate rapidly, most cancer cells in vivo reside in… read more here.
Keywords: pancreatic cancer; slow cycling; cycling state; cancer ... See more keywords
Identification of TOR‐responsive slow‐cycling neoblasts in planarians
Sign Up to like & getrecommendations! Published in 2021 at "EMBO reports"
DOI: 10.15252/embr.202050292
Abstract: Epimorphic regeneration commonly relies on the activation of reserved stem cells to drive new cell production. The planarian Schmidtea mediterranea is among the best regenerators in nature, thanks to its large population of adult stem… read more here.
Keywords: slow cycling; rnalow neoblasts; regeneration; identification tor ... See more keywords
Characterization and functional analysis of a slow-cycling subpopulation in colorectal cancer enriched by cell cycle inducer combined chemotherapy.
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.19638
Abstract: The concept of cancer stem cells has been proposed in various malignancies including colorectal cancer. Recent studies show direct evidence for quiescence slow-cycling cells playing a role in cancer stem cells. There exists an urgent… read more here.
Keywords: cancer; slow cycling; cell; cell cycle ... See more keywords
Slow-Cycling Cells in Glioblastoma: A Specific Population in the Cellular Mosaic of Cancer Stem Cells
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14051126
Abstract: Glioblastoma (GBM) exhibits populations of cells that drive tumorigenesis, treatment resistance, and disease progression. Cells with such properties have been described to express specific surface and intracellular markers or exhibit specific functional features including being… read more here.
Keywords: cancer stem; cycling cells; slow cycling; stem cells ... See more keywords
Polyploid/Multinucleated Giant and Slow-Cycling Cancer Cell Enrichment in Response to X-ray Irradiation of Human Glioblastoma Multiforme Cells Differing in Radioresistance and TP53/PTEN Status
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24021228
Abstract: Radioresistance compromises the efficacy of radiotherapy for glioblastoma multiforme (GBM), the most devastating and common brain tumor. The present study investigated the relationship between radiation tolerance and formation of polyploid/multinucleated giant (PGCC/MGCC) and quiescent/senescent slow-cycling… read more here.
Keywords: cell; slow cycling; response; radioresistance ... See more keywords
Identification and characterization of slow-cycling cells in Ewing sarcoma
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Oncology"
DOI: 10.3892/ijo.2022.5428
Abstract: Ewing sarcoma (ES) is an aggressive primary malignant bone tumor that predominantly affects children and young adults. Multimodal treatment approaches have markedly improved the survival of patients with localized ES. However, local recurrence and distant… read more here.
Keywords: ewing sarcoma; cycling cells; slow cycling; study ... See more keywords