Increased PINK1/Parkin-mediated mitophagy explains the improved brain protective effects of slow rewarming following hypothermia after cardiac arrest in rats
Sign Up to like & getrecommendations! Published in 2020 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2020.113326
Abstract: Cerebral ischemia-reperfusion (I/R) after cardiac arrest (CA) induces mitochondrial dysfunction, and the timely removal of damaged mitochondria by mitophagy is reported to protect against cerebral I/R injury. Therapeutic hypothermia (TH) has become an important component… read more here.
Keywords: hypothermia; slow rewarming; rewarming group; pink1 parkin ... See more keywords
Slow rewarming after hypothermia does not ameliorate white matter injury after hypoxia-ischemia in near-term fetal sheep
Sign Up to like & getrecommendations! Published in 2024 at "Pediatric Research"
DOI: 10.1038/s41390-024-03332-y
Abstract: The optimal rate to rewarm infants after therapeutic hypothermia is unclear. In this study we examined whether slow rewarming after 72 h of hypothermia would attenuate white matter injury. Near-term fetal sheep received sham occlusion (n = 8)… read more here.
Keywords: white matter; term; hypothermia; slow rewarming ... See more keywords